NOS1 Inhibitors
Santa Cruz Biotechnology now offers a broad range of NOS1 Inhibitors. Nitric oxide (NO) has a broad range of biological activities including cell signaling pathways in phylogenetically diverse species. Nitric oxide synthases (NOSs), the enzymes responsible for synthesis of NO, contain an N-terminal oxygenase domain and a C-terminal reductase domain. NOS1 (also designated ncNOS) is a constitutive Ca2+/CaM-dependent form of NOS, whose activity was first identified in neurons. NOS1 Inhibitors offered by Santa Cruz inhibit NOS1 and, in some cases, other cell signaling and nitric oxide synthesis related proteins. View detailed NOS1 Inhibitor specifications, including NOS1 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 31 to 40 of 54 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
7-Nitroindazole sodium salt | 2942-42-9 (non-salt) | sc-221114 sc-221114A | 5 mg 25 mg | $23.00 $48.00 | 1 | |
7-Nitroindazole sodium salt exhibits a unique affinity for nitric oxide synthase (NOS1) by engaging in π-π stacking interactions with aromatic residues within the enzyme's active site. This interaction can stabilize specific conformations of NOS1, potentially altering its enzymatic activity. Additionally, the compound's nitro group may participate in electron-withdrawing effects, influencing the redox state of the enzyme and modulating its reactivity in nitric oxide production pathways. | ||||||
MEG (sulfate) | 3979-00-8 | sc-205381 sc-205381A | 5 mg 10 mg | $158.00 $250.00 | ||
MEG (sulfate) interacts with NOS1 through hydrogen bonding and electrostatic interactions, enhancing the enzyme's structural dynamics. Its sulfate group can facilitate the formation of transient complexes, influencing substrate binding and catalytic efficiency. The compound's unique solubility properties may also affect the local microenvironment around NOS1, potentially altering reaction kinetics and the enzyme's overall activity in nitric oxide synthesis pathways. | ||||||
2-Iminobiotin | 13395-35-2 | sc-202403 sc-202403A sc-202403B sc-202403C sc-202403D sc-202403E sc-202403F | 10 mg 50 mg 100 mg 1 g 5 g 10 g 50 g | $31.00 $66.00 $141.00 $1186.00 $4721.00 $6936.00 $21410.00 | ||
2-Iminobiotin exhibits unique interactions with NOS1, primarily through its ability to form stable complexes via non-covalent interactions. This compound can modulate the enzyme's conformational states, impacting its catalytic mechanisms. Additionally, its structural features may influence the accessibility of the active site, thereby affecting substrate turnover rates. The presence of specific functional groups can also alter the local pH, further influencing NOS1's enzymatic behavior in nitric oxide production. | ||||||
AMT HYDROCHLORIDE | 21463-31-0 | sc-202052 sc-202052A | 10 mg 50 mg | $109.00 $419.00 | ||
AMT Hydrochloride engages with NOS1 through intricate molecular interactions that stabilize enzyme conformations. Its unique structural attributes facilitate the modulation of electron transfer processes, enhancing the enzyme's reactivity. The compound's ability to influence ionic interactions can alter the electrostatic environment around the active site, potentially affecting substrate affinity and reaction kinetics. Furthermore, its solubility characteristics may impact the overall dynamics of NOS1 activity in various biochemical contexts. | ||||||
TRIM | 25371-96-4 | sc-200353 sc-200353A | 100 mg 500 mg | $95.00 $315.00 | ||
TRIM specifically inhibits NOS1, preventing the synthesis of NO in neuronal tissues. | ||||||
L-NIO dihydrochloride | 36889-13-1 | sc-361229 sc-361229A | 10 mg 50 mg | $60.00 $209.00 | 5 | |
L-NIO dihydrochloride exhibits a distinctive capacity to modulate NOS1 activity through specific binding interactions that influence the enzyme's structural dynamics. Its unique functional groups can alter hydrogen bonding patterns, thereby affecting the enzyme's catalytic efficiency. Additionally, the compound's hydrophilic nature enhances its solubility in aqueous environments, which may play a critical role in the accessibility of NOS1 to its substrates, ultimately impacting reaction rates and pathways. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
Gabexate mesylate is characterized by its ability to selectively interact with NOS1, influencing its enzymatic behavior through competitive inhibition. The compound's unique structural features facilitate specific interactions with the active site, altering the enzyme's conformational state. This modulation can lead to changes in reaction kinetics, as the presence of Gabexate mesylate affects substrate binding affinity and turnover rates, ultimately impacting the overall metabolic pathways involving NOS1. | ||||||
α-Guanidinoglutaric acid | 73477-53-9 | sc-202031 | 10 mg | $54.00 | ||
α-Guanidinoglutaric acid exhibits a distinctive capacity to modulate NOS1 activity through allosteric interactions, enhancing its enzymatic efficiency. The compound's unique guanidine group allows for specific hydrogen bonding with key residues in the enzyme, promoting a conformational shift that optimizes substrate accessibility. This interaction can significantly influence the reaction kinetics, altering the rate of nitric oxide production and affecting downstream signaling pathways. | ||||||
3-Bromo-7-nitroindazole | 74209-34-0 | sc-200347 sc-200347A | 5 mg 25 mg | $20.00 $26.00 | 1 | |
3-Bromo-7-nitroindazole is characterized by its ability to selectively inhibit NOS1 through competitive binding at the active site. The presence of the bromine and nitro groups introduces steric hindrance and electronic effects that disrupt enzyme-substrate interactions. This compound's unique structural features facilitate specific π-π stacking with aromatic residues, influencing the enzyme's conformational dynamics and potentially altering its catalytic efficiency and regulatory mechanisms. | ||||||
N-ω-Propyl-L-Arginine | 137361-05-8 | sc-224171 sc-224171A | 5 mg 10 mg | $71.00 $189.00 | 1 | |
NPLA is a selective nNOS inhibitor, targeting NOS1 without much influence on eNOS or iNOS. | ||||||