Molecular structure of 3-Bromo-7-nitroindazole, CAS Number: 74209-34-0
3-Bromo-7-nitroindazole (CAS 74209-34-0)
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Alternate Names:
3-Bromo-7-nitro-1H-indazole
Application:
3-Bromo-7-nitroindazole is a selective inhibitor of NOS1 and NOS3
CAS Number:
74209-34-0
Molecular Weight:
242.03
Molecular Formula:
C7H4BrN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Bromo-7-nitroindazole is a 7-nitro indazole derivative that inhibits bovine NOS3 and rat NOS1 enzyme activity. This compound was also reported to provide significant neuroprotection against ischaemia-induced brain damage in rat models. Experiments suggest that 3-Bromo-7-nitroindazole displays the capacity to prevent effects of MCPG, a metabotropic receptor antagonist. Metabotropic receptors decrease synaptic transmission in murine models.
3-Bromo-7-nitroindazole (CAS 74209-34-0) References
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- Contribution of nitric oxide to the presynaptic inhibition by endothelin ETB receptor of the canine stellate ganglionic transmission. | Yamada, K., et al. 1999. J Pharmacol Exp Ther. 290: 1175-81. PMID: 10454492
- Ischemia-reperfusion injury of the cochlea: effects of an iron chelator and nitric oxide synthase inhibitors. | Tabuchi, K., et al. 2001. Hear Res. 160: 31-6. PMID: 11591488
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- 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP. | Srinivasan, K. and Sharma, SS. 2012. Life Sci. 90: 154-60. PMID: 22075494
- Excessive nNOS/NO/AMPK signaling activation mediated by the blockage of the CBS/H2S system contributes to oxygen‑glucose deprivation‑induced endoplasmic reticulum stress in PC12 cells. | Zhang, R., et al. 2017. Int J Mol Med. 40: 549-557. PMID: 28656194
- Nitric Oxide Synthase Blockade Impairs Spontaneous Calcium Activity in Mouse Primary Hippocampal Culture Cells. | Sokolov, RA., et al. 2023. Int J Mol Sci. 24: PMID: 36768926
- 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. | Bland-Ward, PA. and Moore, PK. 1995. Life Sci. 57: PL131-5. PMID: 7544863
- Possible role of nitric oxide in the development of L-2-chloropropionic acid-induced cerebellar granule cell necrosis. | Widdowson, PS., et al. 1996. Br J Pharmacol. 117: 1761-7. PMID: 8732288
- The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat. | Stagliano, NE., et al. 1997. Brain Res. 759: 32-40. PMID: 9219860
- Neuroprotective effects of the antioxidant LY231617 and NO synthase inhibitors in global cerebral ischaemia. | O'Neill, MJ., et al. 1997. Brain Res. 760: 170-8. PMID: 9237532
- Role of nitric oxide in traumatic brain injury in the rat. | Wada, K., et al. 1998. J Neurosurg. 89: 807-18. PMID: 9817419
Inhibitor of:
Enzyme, GD3 Synthase, GlcNAc kinase, NOS1, NOS3, Plasmodium Aldolase, and PYGM.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Bromo-7-nitroindazole, 5 mg | sc-200347 | 5 mg | $20.00 | |||
3-Bromo-7-nitroindazole, 25 mg | sc-200347A | 25 mg | $26.00 |