Molecular structure of α-Guanidinoglutaric acid, CAS Number: 73477-53-9
α-Guanidinoglutaric acid (CAS 73477-53-9)
Alternate Names:
N-(aminoiminomethyl)-L-glutamic acid
Application:
α-Guanidinoglutaric acid is a linear mixed-type inhibitor of NOS1
CAS Number:
73477-53-9
Molecular Weight:
189.2
Molecular Formula:
C6H11N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
α-Guanidinoglutaric acid, also known as Guanidinoglutaric acid (GGA) is a compound that functions as a linear mixed-type inhibitor of nNOS (neuronal nitric oxide synthase). With a Ki (inhibition constant) of 2.69 µM, α-Guanidinoglutaric acid effectively inhibits the activity of nNOS. Notably, α-Guanidinoglutaric acid acts as an inhibitor of nitric oxide synthase, thereby impeding the production of nitric oxide.
α-Guanidinoglutaric acid (CAS 73477-53-9) References
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- A role for guanidino compounds in the brain. | Hiramatsu, M. 2003. Mol Cell Biochem. 244: 57-62. PMID: 12701810
- Incorporation of N-amidino-pyroglutamic acid into peptides using intramolecular cyclization of alpha-guanidinoglutaric acid. | Burov, S., et al. 2009. J Pept Sci. 15: 760-6. PMID: 19739127
- Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders. | Tachikawa, M. and Hosoya, K. 2011. Fluids Barriers CNS. 8: 13. PMID: 21352605
- Biochemistry and neurotoxicology of guanidino compounds. History and recent advances. | Mori, A. 1987. Pavlov J Biol Sci. 22: 85-94. PMID: 2821470
- The lactam of alpha-guanidinoglutaric acid (1-amidino-2-pyrrolidone-5-carboxylic acid). | Natelson, S. 1986. Anal Biochem. 156: 31-7. PMID: 2874749
- Convulsive activity of alpha-guanidinoglutaric acid and the possible involvement of 5-hydroxytryptamine in the alpha-guanidinoglutaric acid-induced seizure mechanism. | Shiraga, H., et al. 1986. J Neurochem. 47: 1832-6. PMID: 3772379
- Effect of guanidino compounds on hen egg development. | Seki, S., et al. 1982. Adv Exp Med Biol. 153: 465-70. PMID: 7164920
- alpha-Guanidinoglutaric acid in cobalt-induced epileptogenic cerebral cortex of cats. | Mori, A., et al. 1980. J Neurochem. 35: 603-5. PMID: 7452277
- alpha-Guanidinoglutaric acid, an endogenous convulsant, as a novel nitric oxide synthase inhibitor. | Yokoi, I., et al. 1994. J Neurochem. 63: 1565-7. PMID: 7523594
- Structure-activity relationships of arginine analogues on nitric oxide synthase activity in the rat brain. | Yokoi, I., et al. 1994. Neuropharmacology. 33: 1261-5. PMID: 7532812
- alpha-Guanidinoglutaric acid as a free radical generator. | Mori, A., et al. 1995. Biochem Mol Biol Int. 37: 371-4. PMID: 8673021
- Seizures induced by alpha-guanidinoglutaric acid, a nitric oxide synthase inhibitor, are controlled by L-arginine. | Habu, H., et al. 1996. Biochem Mol Biol Int. 39: 87-95. PMID: 8799331
Inhibitor of:
Enzyme, and NOS1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Guanidinoglutaric acid, 10 mg | sc-202031 | 10 mg | $55.00 |