Molecular structure of TRIM, CAS Number: 25371-96-4
TRIM (CAS 25371-96-4)
Application:
TRIM is a NOS1 (nNOS) and NOS2 (iNOS) inhibitor
CAS Number:
25371-96-4
Purity:
98%
Molecular Weight:
212.2
Molecular Formula:
C10H7F3N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TRIM is an inhibitor of NOS1 (nNOS) and NOS2 (iNOS) with IC50 values of 28.2 μM and 27.0 μM, respectively. Studies involving mice suggest that TRIM is a useful tool in determining the roles of NOS in the central nervous system. In addition, TRIM inhibits acetic acid induced abdominal constriction of mice, thus displaying its antinociceptive ability. Furthermore, TRIM interferes with the binding between arginine and tetrahydrobiopterin.
TRIM (CAS 25371-96-4) References
- Role of nitric oxide on in vitro human eosinophil migration. | Thomazzi, SM., et al. 2001. Biochem Pharmacol. 62: 1417-21. PMID: 11709202
- Inhibitory effects of NO on carotid body: contribution of neural and endothelial nitric oxide synthase isoforms. | Valdés, V., et al. 2003. Am J Physiol Lung Cell Mol Physiol. 284: L57-68. PMID: 12388352
- Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. | Volke, V., et al. 2003. Behav Brain Res. 140: 141-7. PMID: 12644287
- Positive N-methyl-D-aspartate receptor modulation by selective glycine transporter-1 inhibition in the rat dorsal spinal cord in vivo. | Whitehead, KJ., et al. 2004. Neuroscience. 126: 381-90. PMID: 15207356
- A store-operated current (SOC) mediates oxytocin autocontrol in the developing rat hypothalamus. | Tobin, V., et al. 2006. Eur J Neurosci. 24: 400-4. PMID: 16836632
- Different roles of nitric oxide synthase isoforms in cardiopulmonary resuscitation in pigs. | Wu, D., et al. 2007. Resuscitation. 73: 144-53. PMID: 17316954
- Neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole augment the effects of antidepressants acting via serotonergic system in the forced swimming test in rats. | Ulak, G., et al. 2008. Pharmacol Biochem Behav. 90: 563-8. PMID: 18565575
- Effects of inhibition of neuronal nitric oxide synthase on basal retinal blood flow regulation. | Tummala, SR., et al. 2009. Exp Eye Res. 89: 801-9. PMID: 19646435
- The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. | Handy, RL., et al. 1995. Br J Pharmacol. 116: 2349-50. PMID: 8581267
- Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. | Handy, RL., et al. 1996. Br J Pharmacol. 119: 423-31. PMID: 8886430
- Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro. | Wu, J., et al. 1997. Neuroscience. 78: 393-8. PMID: 9145796
- Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. | Zanardo, RC., et al. 1997. Proc Natl Acad Sci U S A. 94: 14111-4. PMID: 9391161
- Neurogenic oedema and vasodilatation: effect of a selective neuronal NO inhibitor. | Towler, PK., et al. 1998. Neuroreport. 9: 1513-8. PMID: 9631458
Inhibitor of:
NOS1, NOS2, and NOS3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRIM, 100 mg | sc-200353 | 100 mg | $95.00 | |||
TRIM, 500 mg | sc-200353A | 500 mg | $315.00 |