L-NIO dihydrochloride (CAS 36889-13-1)
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L-NIO dihydrochloride is a chemical compound utilized as a selective inhibitor of nitric oxide synthase (NOS), specifically the endothelial NOS (eNOS) isoform. In biochemical research, it is employed to investigate the role of eNOS in the production of nitric oxide (NO) within the cardiovascular system. By inhibiting eNOS activity, L-NIO dihydrochloride aids in the elucidation of NO-related signaling pathways and their impact on vascular tone and blood flow regulation. This compound is also used in studies exploring the implications of NO in angiogenesis and endothelial cell function. Additionally, L-NIO dihydrochloride is instrumental in examining the contributions of NO to oxidative stress and inflammatory responses within the vascular system. Its role as an inhibitor makes it useful for researchers studying the complex physiological and pathological processes mediated by NO.
L-NIO dihydrochloride (CAS 36889-13-1) References
- beta cell cytoprotective strategies: establishing the relative roles for iNOS and ROS. | McCabe, C., et al. 2006. Biochem Biophys Res Commun. 342: 1240-8. PMID: 16516156
- Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. | Hattori, H., et al. 2010. Proc Natl Acad Sci U S A. 107: 3546-51. PMID: 20142487
- Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis. | Miozza, V., et al. 2010. Oral Dis. 16: 801-6. PMID: 20561219
- Angiopoietins regulate vascular reactivity after haemorrhagic shock in rats through the Tie2-nitric oxide pathway. | Xu, J., et al. 2012. Cardiovasc Res. 96: 308-19. PMID: 22869617
- Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. | Jian, Z., et al. 2014. Sci Signal. 7: ra27. PMID: 24643800
- Endothelial dysfunction impairs vascular neurotransmission in tail arteries. | Sousa, JB., et al. 2015. Neurochem Int. 80: 7-13. PMID: 25447765
- Endothelial and Neuronal Nitric Oxide Activate Distinct Pathways on Sympathetic Neurotransmission in Rat Tail and Mesenteric Arteries. | Sousa, JB., et al. 2015. PLoS One. 10: e0129224. PMID: 26075386
- PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives. | Asati, V., et al. 2016. Eur J Med Chem. 109: 314-41. PMID: 26807863
- Mesenchymal stem cells suppress cardiac alternans by activation of PI3K mediated nitroso-redox pathway. | Sattayaprasert, P., et al. 2016. J Mol Cell Cardiol. 98: 138-45. PMID: 27238412
- Heparin-binding EGF-like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis. | Zhou, Y., et al. 2017. Pediatr Res. 82: 490-500. PMID: 28422949
- Synergistic Effects of Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) Combination in Angiogenesis Behavior in EAhy 926 Cells. | Zhou, X., et al. 2017. Medicines (Basel). 4: PMID: 29160857
- NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells. | Negri, S., et al. 2021. Cell Calcium. 99: 102454. PMID: 34454368
- Activation of endothelial NO synthase and P2X7 receptor modification mediates the cholinergic control of ATP-induced interleukin-1β release by mononuclear phagocytes. | Richter, K., et al. 2023. Front Immunol. 14: 1140592. PMID: 36969210
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-NIO dihydrochloride, 10 mg | sc-361229 | 10 mg | $60.00 | |||
L-NIO dihydrochloride, 50 mg | sc-361229A | 50 mg | $209.00 |