NMDA Inhibitors
Santa Cruz Biotechnology now offers a broad range of NMDA Inhibitors. Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. NMDA Inhibitors offered by Santa Cruz inhibit NMDA and, in some cases, other neurotransmission and neural development related proteins. View detailed NMDA Inhibitor specifications, including NMDA Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 21 to 30 of 67 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
O-Phospho-L-serine | 407-41-0 | sc-202257 | 1 g | $37.00 | ||
O-Phospho-L-serine serves as a significant modulator of NMDA receptor activity, characterized by its phosphorylated amino acid structure that enables specific interactions with receptor binding sites. This compound influences the receptor's conformational dynamics, promoting enhanced calcium ion flow and synaptic signaling. Its unique phosphorylation state contributes to distinct signaling pathways, impacting neuronal communication and synaptic plasticity through intricate molecular mechanisms. | ||||||
Kynurenic acid | 492-27-3 | sc-202683 sc-202683A sc-202683B | 250 mg 1 g 5 g | $26.00 $57.00 $138.00 | 6 | |
Kynurenic acid is a notable endogenous compound that acts as a competitive antagonist at NMDA receptors, influencing excitatory neurotransmission. Its unique structure allows it to interact with the receptor's glycine binding site, modulating receptor activity and calcium influx. This compound is involved in various metabolic pathways, particularly in the kynurenine pathway, where it plays a role in balancing neuroprotective and neurotoxic effects, thereby impacting neuronal health and function. | ||||||
Ro 25-6981 maleate | 1312991-76-6 | sc-204887 sc-204887A sc-204887B | 1 mg 10 mg 50 mg | $109.00 $232.00 $949.00 | ||
A selective antagonist for the GluN2B subunit of the NMDA receptor. | ||||||
Amantadine hydrochloride | 665-66-7 | sc-217619 | 5 g | $47.00 | 1 | |
Amantadine hydrochloride is a unique compound that exhibits distinct interactions with NMDA receptors, functioning as a non-competitive antagonist. Its molecular structure facilitates binding to the receptor, altering ion channel dynamics and influencing synaptic plasticity. This compound also engages in complex reaction kinetics, affecting neurotransmitter release and modulating intracellular signaling pathways. Its behavior as an acid halide contributes to its solubility and stability in various environments, enhancing its reactivity in biochemical contexts. | ||||||
4-oxo-1,4-dihydroquinoline-2-carboxylic acid | 13593-94-7 | sc-277591 | 250 mg | $230.00 | ||
4-Oxo-1,4-dihydroquinoline-2-carboxylic acid demonstrates intriguing interactions with NMDA receptors, acting as a modulator of excitatory neurotransmission. Its unique molecular configuration allows for selective binding, influencing receptor conformational states and ion permeability. The compound's reactivity as an acid halide enhances its ability to form stable intermediates, facilitating diverse biochemical pathways. Additionally, its solubility characteristics promote effective diffusion in cellular environments, impacting overall neurophysiological responses. | ||||||
CGP 37849 | 127910-31-0 | sc-203880 sc-203880A | 10 mg 50 mg | $179.00 $760.00 | ||
A competitive NMDA antagonist; it competes with glutamate for binding, thus preventing receptor activation. | ||||||
7-Chlorokynurenic acid | 18000-24-3 | sc-358717 sc-358717A | 10 mg 50 mg | $83.00 $349.00 | ||
7-Chlorokynurenic acid exhibits a distinctive role in modulating NMDA receptor activity through competitive antagonism. Its structural features enable it to interact with specific binding sites, altering receptor dynamics and ion channel conductance. The compound's reactivity as an acid halide contributes to its ability to form transient complexes, influencing downstream signaling pathways. Furthermore, its hydrophilic nature enhances solubility, promoting effective cellular uptake and distribution. | ||||||
DL-2-Amino-4-phosphonobutanoic acid (AP4) | 20263-07-4 | sc-200430 sc-200430A | 50 mg 100 mg | $34.00 $67.00 | ||
DL-2-Amino-4-phosphonobutanoic acid (AP4) serves as a selective antagonist of NMDA receptors, characterized by its unique ability to inhibit excitatory neurotransmission. Its structural conformation allows for specific interactions with the receptor's allosteric sites, modulating ion flow and synaptic plasticity. The compound's phosphonate group enhances its stability and reactivity, facilitating interactions with metal ions and influencing intracellular signaling cascades. Additionally, its zwitterionic nature contributes to its solubility in biological systems, promoting effective engagement with target receptors. | ||||||
LY 235959 | 137433-06-8 | sc-361239 sc-361239A | 10 mg 50 mg | $179.00 $756.00 | ||
A competitive antagonist that binds to the glutamate site, inhibiting receptor activation. | ||||||
Felbamate | 25451-15-4 | sc-203579 sc-203579A | 10 mg 50 mg | $101.00 $373.00 | ||
Felbamate is a compound that exhibits unique interactions with NMDA receptors, acting as a modulator of excitatory neurotransmission. Its structure allows for selective binding to the receptor, influencing ion channel dynamics and synaptic responses. The presence of specific functional groups enhances its reactivity, enabling it to participate in diverse biochemical pathways. Furthermore, Felbamate's ability to form hydrogen bonds contributes to its solubility and stability in various environments, facilitating its engagement with target sites. | ||||||