Molecular structure of Ro 25-6981 maleate, CAS Number: 1312991-76-6
Ro 25-6981 maleate (CAS 1312991-76-6)
Application:
Ro 25-6981 maleate is a potent NMDA receptor antagonist
CAS Number:
1312991-76-6
Molecular Weight:
455.55
Molecular Formula:
C22H29NO2 C4H4O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ro 25-6981 maleate is a potent and selective NMDA antagonist. Ro 25-6981 maleate is a selective activity-dependent blocker of the NMDAε2 subunit-receptors with IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively.
Ro 25-6981 maleate (CAS 1312991-76-6) References
Fischer et al (1997) Ro 25-6981, a highly potent and selective blocker of N-Methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J.Pharmacol.Exp.Ther. 283 1285. Lynch et al (2001) Pharmacological characterization of interactions of RO 25-6981 with the NR2B (e2) subunit. Eur.J.Pharmacol. 416 185. Kosowski and Liljequist (2004) The NR2B- selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(±)-(R*,S*)-a-(4-hydroxyphenyl)-b-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamine release in the nucleus accumbens. J.Pharmacol.Exp.Ther. 311 560.Inhibitor of:
GRIN1, LRRTM2, NDST, neuroligin 2, neuropsin, NMDA, NMDA epsilon 2, NMDA epsilon 3, and PAMCI.Activator of:
HCNP, and NMDAε4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro 25-6981 maleate, 1 mg | sc-204887 | 1 mg | $107.00 | |||
Ro 25-6981 maleate, 10 mg | sc-204887A | 10 mg | $227.00 | |||
Ro 25-6981 maleate, 50 mg | sc-204887B | 50 mg | $930.00 |