Date published: 2025-11-29

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O-Phospho-L-serine (CAS 407-41-0)

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Alternate Names:
L-2-Amino-3-hydroxypropanoic acid 3-phosphate
Application:
O-Phospho-L-serine is a competitive NMDA antagonist/ group III mGluR agonist
CAS Number:
407-41-0
Purity:
≥97%
Molecular Weight:
185.07
Molecular Formula:
C3H8NO6P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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O-Phospho-L-serine, a naturally occurring phospholipid, holds a vital presence within the cell membranes of all eukaryotic cells. Functioning as a small molecule, it plays a role in cell signaling pathways and participates in various cellular processes, including cell growth, differentiation, and apoptosis. PS assumes the significant responsibility of regulating cell membrane structure and function while actively engaging in diverse metabolic and biochemical pathways. The precise mechanism of action of O-Phospho-L-serine remains partially elucidated. It is understood that Phosphoserine binds to specific proteins, such as G proteins, thereby modulating their activity by either activating or inhibiting them. Moreover, Phosphoserine demonstrates an ability to interact with other proteins like nuclear receptors, thereby exerting regulatory control over their activity. Additionally, O-Phospho-L-serine engages in interactions with other phospholipids, such as phosphatidylinositol, consequently influencing their activity as well. O-Phospho-L-serine may act to elicit a range of biochemical and physiological effects, including the regulation of cell proliferation, differentiation, and apoptosis. It also participates in vital functions such as cell signaling pathways, membrane structure and function, as well as metabolic pathways.


O-Phospho-L-serine (CAS 407-41-0) References

  1. A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1.  |  Mino, K. and Ishikawa, K. 2003. FEBS Lett. 551: 133-8. PMID: 12965218
  2. L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes.  |  Klunk, WE., et al. 1991. J Neurochem. 56: 1997-2003. PMID: 1673996
  3. O-phospho-L-serine, multi-functional excipient for B domain deleted recombinant factor VIII.  |  Miclea, RD., et al. 2007. AAPS J. 9: E251-9. PMID: 17907766
  4. O-phospho-L-serine: a modulator of bone healing in calcium-phosphate cements.  |  Mai, R., et al. 2008. Biomed Tech (Berl). 53: 229-33. PMID: 18803525
  5. O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis.  |  O'Leary, SE., et al. 2008. Biochemistry. 47: 11606-15. PMID: 18842002
  6. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina.  |  Bailey, TJ., et al. 2010. Exp Eye Res. 91: 601-12. PMID: 20696157
  7. O-phospho-l-serine mediates hyporesponsiveness toward FVIII in hemophilia A-murine model by inducing tolerogenic properties in dendritic cells.  |  Fathallah, AM., et al. 2014. J Pharm Sci. 103: 3457-3463. PMID: 25266204
  8. Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis.  |  Kobylarz, MJ., et al. 2016. Biochemistry. 55: 927-39. PMID: 26794841
  9. Identification of amino acid residues important for recognition of O-phospho-l-serine substrates by cysteine synthase.  |  Takeda, E., et al. 2021. J Biosci Bioeng. 131: 483-490. PMID: 33563496
  10. Refined Structures of O-Phospho-l-serine and Its Calcium Salt by New Multinuclear Solid-State NMR Crystallography Methods.  |  Mathew, R., et al. 2021. J Phys Chem B. 125: 10985-11004. PMID: 34553936
  11. The effects of okadaic acid-treated SH-SY5Y cells on microglia activation and phagocytosis.  |  Amonruttanapun, P., et al. 2022. Cell Biol Int. 46: 234-242. PMID: 34748253
  12. Nuclear Magnetic Resonance and Metadynamics Simulations Reveal the Atomistic Binding of l-Serine and O-Phospho-l-Serine at Disordered Calcium Phosphate Surfaces of Biocements.  |  Mathew, R., et al. 2022. Chem Mater. 34: 8815-8830. PMID: 36248225
  13. Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor.  |  Thomsen, C. and Suzdak, PD. 1993. Neuroreport. 4: 1099-101. PMID: 8106006
  14. Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis.  |  Borodezt, K. and D'Mello, SR. 1998. J Neurosci Res. 53: 531-41. PMID: 9726424

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

O-Phospho-L-serine, 1 g

sc-202257
1 g
$36.00