7-Chlorokynurenic acid CAS: 18000-24-3
MF: C10H6CINO3
MW: 223.62
An NMDA receptor antagonist and inhibitor of EAAT.

7-Chlorokynurenic acid (CAS 18000-24-3)

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Alternate Names: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid
Application: 7-Chlorokynurenic acid is an NMDA receptor antagonist and inhibitor of EAAT
CAS Number: 18000-24-3
Purity: ≥98%
Molecular Weight: 223.62
Molecular Formula: C10H6CINO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

7-Chlorokynurenic acid is an NMDA receptor antagonist acting at the glycine site. 7-Chlorokynurenic acid acts as a potent competitive inhibitor of EAAT (L-glutamate transporter) into synaptic vesicles.


References

1. Kemp, J.A., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 6547-6550. PMID: 2842779
2. Kretschmer, B.D., et al. 1995. Eur. J. Pharmacol. 280: 37-45. PMID: 7498252
3. Bartlett, R.D., et al. 1999. Neuropharmacology. 37: 839-846. PMID: 9776380

Physical State :
Solid
Solubility :
Soluble in DMSO (14 mg/ml), 0.1 M NaOH (13.7 mg/ml), and water (partly miscible).
Storage :
Store at 4° C
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Glutamate NMDA receptor: IC50 = 320 nM (rat); Glutamate [NMDA] receptor subunit 3B: IC50 = 8 µM (rat)
Ki Data :
Vesicular glutamate transporter 3: Ki= 590 µM (rat)
pK Values :
pKa: 0.90 (Predicted), pKb: 9.79 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VB1947166
PubChem CID :
1884
MDL Number :
MFCD00069227
EC Number :
241-913-6
SMILES :
C1=CC2=C(C=C1Cl)NC(=CC2=O)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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