4-oxo-1,4-dihydroquinoline-2-carboxylic acid (CAS 13593-94-7)

物理状态 :

Solid

溶解度 :

Soluble in water (~0.9%) at 100° C, hot alcohol, 0.1 N NaOH (4 mg/mL), DMSO (5 mg/mL), and 1.0 M NaOH (50 mg/mL-clear, pale yellow solution). Insoluble in ether.

保存 :

Store at room temperature

熔点 :

249-250° C

沸点 :

~358.4° C at 760 mmHg (Predicted)

密度 :

~1.4 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.64 (Predicted)

IC50 :

Glutamate receptor ionotropic, AMPA: IC₅₀ = 101 µM (rat); Glutamate NMDA receptor: IC₅₀ = 13.8 µM (rat); GPR35: EC₅₀50 = 152 µM (human)

Ki 数据 :

Glutamate (NMDA) receptor subunit zeta 1: K_i= 5.4 µM (rat); Vesicular glutamate transporter 3: K_i= 1.3 mM (rat)

pK值 :

pK_a: 3.49 (Predicted), pK_b: 0.36 (Predicted)

德国水公害等级 :

3

RTECS :

VB2080000

PubChem CID :

Merck 索引 :

14: 5327

MDL 号码 :

MFCD00006753

EC号码 :

207-751-5

Beilstein 注册 :

147451

SMILES :

C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O