Molecular structure of CGP 37849, CAS Number: 127910-31-0
CGP 37849 (CAS 127910-31-0)
Application:
CGP 37849 is a potent antagonist at NMDA receptors
CAS Number:
127910-31-0
Molecular Weight:
209.14
Molecular Formula:
C6H12NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
CGP 37849 is a potent, competitive, and selective NMDA antagonist with a Ki value of 35 nM.
CGP 37849 (CAS 127910-31-0) References
- The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats. | Przegaliński, E., et al. 2000. Neuropharmacology. 39: 1858-64. PMID: 10884566
- Anticonvulsant activity of two orally active competitive N-methyl-D-aspartate antagonists, CGP 37849 and CGP 39551, against sound-induced seizures in DBA/2 mice and photically induced myoclonus in Papio papio. | Chapman, AG., et al. 1991. Epilepsia. 32: 578-87. PMID: 1678345
- CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity. | Fagg, GE., et al. 1990. Br J Pharmacol. 99: 791-7. PMID: 1972895
- Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551. | Pozza, MF., et al. 1990. Eur J Pharmacol. 182: 91-100. PMID: 1976098
- The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents. | Schmutz, M., et al. 1990. Naunyn Schmiedebergs Arch Pharmacol. 342: 61-6. PMID: 1976233
- CGP 37849 and CGP 39551: novel competitive N-methyl-D-aspartate receptor antagonists with potent oral anticonvulsant activity. | Fagg, GE., et al. 1990. Prog Clin Biol Res. 361: 421-7. PMID: 1981260
- Central effects of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in mice. | Maj, J., et al. 1993. Pol J Pharmacol. 45: 349-60. PMID: 7906989
- Some central effects of CGP 37849 and CGP 39551, the competitive NMDA receptor antagonists: potential antiparkinsonian activity. | Maj, J., et al. 1993. J Neural Transm Park Dis Dement Sect. 6: 53-62. PMID: 8105798
- Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats. | De Sarro, G., et al. 1996. Brain Res. 734: 91-7. PMID: 8896813
- Effects of the competitive N-methyl-D-aspartate antagonist CGP 37849 and its ethylester CGP 39551 on N-methyl-D-aspartate-evoked whole-cell currents in cultured spinal neurones and on vestibular stimulation-induced seizures in EL mice. | D'Hooge, R., et al. 1998. Arzneimittelforschung. 48: 1121-5. PMID: 9893924
Inhibitor of:
NMDA.Activator of:
NMDAζ1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CGP 37849, 10 mg | sc-203880 | 10 mg | $179.00 | |||
CGP 37849, 50 mg | sc-203880A | 50 mg | $760.00 |