NKX1-1 Activators
NKX1-1 activators pertain to a class of chemical compounds that interact with and modulate the activity of the NKX1-1 protein. The NKX1-1 protein is a transcription factor, which is a type of protein that binds to specific DNA sequences and controls the transfer (or transcription) of genetic information from DNA to messenger RNA. Transcription factors like NKX1-1 are critical in regulating a myriad of biological processes by turning genes on or off. NKX1-1 activators, therefore, are molecules that can influence the biological pathways under the control of this transcription factor by enhancing its activity. This activation can lead to an increase in the transcription of genes that are targets of NKX1-1.
The structural diversity of NKX1-1 activators can be extensive, encompassing small organic molecules, peptides, or even larger biomolecular complexes. Their interactions with the NKX1-1 protein can vary from direct binding to allosteric modulation, which in turn can affect the conformation of the NKX1-1 protein, modulate its binding to DNA, or alter its interaction with other proteins involved in the transcriptional machinery. The nature of these interactions is typically characterized by specificity and affinity, which are essential for the precise modulation of the protein's function. Understanding the mechanics of how NKX1-1 activators function at a molecular level involves detailed studies of their structure-activity relationships, which can elucidate the characteristics of their binding sites, the dynamics of their interaction with NKX1-1, and the consequent biochemical pathways that are affected by their activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate transcription factors such as NKX1-1, enhancing its transcriptional activity on target genes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid acts as a ligand for nuclear retinoic acid receptors (RARs) which heterodimerize with retinoid X receptors (RXRs). This complex can bind to retinoic acid response elements (RARE) in the promoter regions of target genes, potentially including those regulated by NKX1-1, thus enhancing NKX1-1's transcriptional activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 beta (GSK-3β), which can lead to the stabilization and activation of transcription factors involved in developmental processes, potentially enhancing the activity of NKX1-1 by promoting its stability and nuclear localization. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor (HDACi), leading to a more relaxed chromatin structure and increased transcription of certain genes. This can enhance the transcriptional activity of NKX1-1 by providing easier access to its target DNA sequences. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
T3 hormone binds to thyroid hormone receptors (TRs) which can regulate gene expression by binding to thyroid response elements (TREs) on DNA. This can enhance NKX1-1 transcriptional activity by affecting genes that interact with or are co-regulated by NKX1-1. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can activate H1 or H2 receptors, which through different G-protein-coupled pathways can lead to the activation of transcription factors. This can enhance the transcriptional activity of NKX1-1 if it regulates or is regulated by genes responsive to histamine signaling. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Db-cAMP is a cAMP analog that can activate PKA, leading to the phosphorylation of proteins including transcription factors. This can enhance NKX1-1 activity by mimicking the effect of increased intracellular cAMP levels. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular cAMP, activating PKA. PKA can then phosphorylate transcription factors, potentially enhancing the activity of NKX1-1 in target gene transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine is a DNA methyltransferase inhibitor, which leads to demethylation of DNA and potentially reactivation of silenced genes. This can enhance NKX1-1 activity if methylation is suppressing genes that are targets or regulators of NKX1-1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is another HDAC inhibitor, which can lead to a more relaxed chromatin state and potentially enhance NKX1-1's ability to access and activate transcription of its target genes. | ||||||