Ninjurin-2 Inhibitors
Chemical inhibitors of Ninjurin-2 can play a role in the functional disruption of this protein by targeting processes essential for its activity, particularly those related to cell migration and adhesion. The extracellular matrix (ECM) is a crucial component that cells interact with during these processes, and matrix metalloproteinases (MMPs) are the enzymes responsible for remodeling the ECM. SB-3CT, a selective inhibitor of MMP-2, directly prevents the degradation of ECM components, thereby inhibiting the migration and interactions of cells where Ninjurin-2 is involved. Similarly, Marimastat and Ilomastat, both broad-spectrum MMP inhibitors, can hinder ECM breakdown, which is a prerequisite for the cell migration and adhesion functions that Ninjurin-2 supports. By impeding the normal function of various MMPs, these inhibitors can indirectly lead to the inhibition of Ninjurin-2's role in cell movement and interaction with its environment.
MMPs like MMP-14 and MMP-13 are specifically inhibited by NSC 405020 and WAY-170523, respectively, which further disrupts the ECM remodeling process and, consequently, the cellular functions involving Ninjurin-2. TAPI-0, an inhibitor of the tumor necrosis factor-alpha converting enzyme (TACE), also contributes to this disruption by blocking a different aspect of ECM interaction, further adding to the inhibition of Ninjurin-2's function in cell adhesion and migration. PD-166793, Prinomastat, Ro 32-3555, and AG3340 (also known as prinomastat) all share a similar mechanism of action, targeting MMP activity to prevent ECM degradation, thereby impeding the functional role of Ninjurin-2 in related cellular processes. BB-2516, another name for Marimastat, adds to this collective inhibitory effect on Ninjurin-2 by ensuring that the ECM remains intact, which is essential for the functional inhibition of Ninjurin-2's role in the physiological processes of cell migration and adhesion.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $102.00 $388.00 | 15 | |
SB-3CT is a selective inhibitor of matrix metalloproteinase 2 (MMP-2). Ninjurin-2 is known to be involved in cell migration and adhesion, processes in which MMPs are critically involved. By inhibiting MMP-2, SB-3CT can disrupt the extracellular matrix remodeling, which is a necessary condition for the functional activity of Ninjurin-2 in facilitating cell movement and interaction with the extracellular matrix. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Ilomastat, also known as GM6001, is another broad-spectrum MMP inhibitor. By blocking MMP activity, it can inhibit the remodeling of the extracellular matrix, thereby impeding the cell migration and adhesion functions that Ninjurin-2 is involved in, leading to its functional inhibition. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Batimastat is an MMP inhibitor that can prevent the degradation of the extracellular matrix. By doing so, it can interfere with the cell migration and adhesion processes where Ninjurin-2 plays a role, leading to the functional inhibition of Ninjurin-2. | ||||||
NSC 405020 | 7497-07-6 | sc-477738 | 10 mg | $105.00 | ||
NSC 405020 specifically targets MMP-14, an enzyme involved in the cleavage of extracellular matrix components. Inhibiting MMP-14 can reduce the cell migration and adhesion capabilities where Ninjurin-2 is functionally involved, thereby inhibiting its function. | ||||||
PD166793 | 199850-67-4 | sc-202709 | 5 mg | $150.00 | 6 | |
PD-166793 is an MMP inhibitor that can prevent the breakdown of the extracellular matrix, a necessary step for cell migration and adhesion that involves Ninjurin-2. The inhibition of MMPs by PD-166793 can thus functionally inhibit Ninjurin-2's role in these processes. | ||||||
Prinomastat | 192329-42-3 | sc-507449 | 5 mg | $190.00 | ||
Prinomastat is an MMP inhibitor that impedes the degradation of the extracellular matrix. By blocking the activity of MMPs, prinomastat can interfere with the cell migration and adhesion processes, where Ninjurin-2 is active, leading to its functional inhibition. | ||||||
Ro 32-3555 | 190648-49-8 | sc-296277 | 10 mg | $413.00 | 2 | |
Ro 32-3555 is an MMP inhibitor, which can hinder the remodeling of the extracellular matrix that is crucial for cell migration and adhesion, processes that involve the function of Ninjurin-2, resulting in its inhibition. | ||||||
WAY 170523 | 307002-73-9 | sc-361402 sc-361402A | 1 mg 10 mg | $275.00 $595.00 | 1 | |
WAY-170523 is a selective inhibitor of MMP-13, an enzyme involved in extracellular matrix remodeling. By inhibiting MMP-13, this chemical can disrupt the cell migration and adhesion processes that Ninjurin-2 is known to influence, thus inhibiting its function. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
BB-2516, also known as marimastat, is an MMP inhibitor that prevents the breakdown of the extracellular matrix, thereby hindering the process of cell migration and adhesion in which Ninjurin-2 functions, leading to the functional inhibition of Ninjurin-2. | ||||||