Ninjurin-2 Activators
Ninjurin-2 Activators represent a diverse group of chemical compounds that enhance the functional activity of Ninjurin-2 through various signaling mechanisms. Forskolin and Dibutyryl-cAMP, by increasing intracellular cAMP levels, activate protein kinase A (PKA), which is known to phosphorylate targets involved in neural growth and repair, thereby facilitating Ninjurin-2's role in these processes. Similarly, inhibitors such as Rolipram, by preventing cAMP degradation, indirectly support the enhancement of Ninjurin-2's functions. Sphingosine-1-phosphate and its analog FTY720, through receptor-mediated signaling, enhance cellular survival and proliferation, which are processes where Ninjurin-2 is presumably active, especially in the context of neural regeneration. Kinase inhibitors like Epigallocatechin gallate (EGCG) and K252a, by reducing competitive kinase signaling, may allow for greater Ninjurin-2 activity in neural cell adhesion andmigration. LY294002, by modulating PI3K/Akt signaling, and PD 98059, an MEK inhibitor, both have the potential to influence cellular survival signals, thus indirectly promoting pathways that could enhance the efficacy of Ninjurin-2 in promoting neuroregeneration and axonal sprouting. The action of Ionomycin, elevating intracellular calcium, may activate calcium-dependent signaling pathways, thereby enhancing Ninjurin-2's roles in neural pathfinding and regeneration.
The biochemical landscape that Ninjurin-2 activators operate within is further nuanced by Anandamide, which engages with cannabinoid receptors, potentially influencing neural development and repair processes where Ninjurin-2 is implicated. The GSK-3 inhibitor SB 216763 could upregulate signaling pathways that favor Ninjurin-2's involvement in neuroprotection and axonal growth, enhancing its functional activity. These activators collectively facilitate the functional enhancement of Ninjurin-2, a protein involved in neuronal communication and regeneration, by targeting and influencing specific signaling pathways without altering protein expression levels directly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP may enhance Ninjurin-2 related signaling by activating PKA, which could phosphorylate proteins in pathways where Ninjurin-2 is functionally involved, particularly in nerve regeneration and cell migration. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor, which prevents the breakdown of cAMP. Higher cAMP levels could lead to the activation of pathways involving Ninjurin-2, thus enhancing its role in processes such as neuronal growth and repair. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate interacts with its G protein-coupled receptors to promote cellular proliferation and survival. This signaling may enhance Ninjurin-2 action by supporting neuronal survival and aiding in neurite outgrowth. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that may prevent the phosphorylation of proteins that compete with pathways involving Ninjurin-2, thereby potentially enhancing Ninjurin-2's role in neural cell adhesion and migration. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can modulate the PI3K/Akt pathway. By doing so, it may alter cellular survival signals, potentially enhancing Ninjurin-2-mediated pathways that promote neuroregeneration. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore which elevates intracellular calcium levels, potentially enhancing Ninjurin-2 signaling involved in calcium-dependent processes such as neural pathfinding and regeneration. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720, after phosphorylation, acts similarly to sphingosine-1-phosphate and could therefore enhance Ninjurin-2 signaling by promoting neuroprotective pathways and aiding in recovery from neural injury. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which may shift signaling dynamics to support pathways that Ninjurin-2 is involved in, particularly in axonal sprouting and neuronal repair. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that penetrates cell membranes to activate cAMP-dependent pathways, potentially enhancing Ninjurin-2's role in neuronal communication and regeneration. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $126.00 $210.00 $488.00 | 19 | |
K252a is a kinase inhibitor that could enhance Ninjurin-2 signaling by reducing competitive kinase activity, potentially improving the protein's functional involvement in neuronal regeneration. | ||||||