NFκB p52 Inhibitors
Common NFκB p52 Inhibitors include, but are not limited to Curcumin CAS 458-37-7, BAY 11-7082 CAS 19542-67-7, Resveratrol CAS 501-36-0, D,L-Sulforaphane CAS 4478-93-7 and (-)-Epigallocatechin Gallate CAS 989-51-5.
Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) represents a family of transcription factors playing a central role in regulating various cellular processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis, and apoptosis. The NFκB family consists of several members, including RelA (p65), RelB, c-Rel, p50 (NFκB1), and p52 (NFκB2). Among these, p52 is an essential component, often forming heterodimers with other family members like RelB to regulate specific gene sets. The p52 protein is generated from the proteolytic processing of its precursor p100, and this conversion is a crucial step for the activation of the non-canonical NFκB pathway. This pathway is unique in its reliance on the NFκB-inducing kinase (NIK) and subsequent activation of the IκB kinase alpha (IKKα), leading to p100 processing to p52.
NFκB p52 inhibitors are molecules designed to specifically target and modulate the activity or levels of the p52 component of the NFκB family. Their mode of action may involve direct interaction with the p52 protein or by impeding its generation from its precursor p100. Furthermore, these inhibitors might target upstream signaling events leading to p52 activation, such as the interference with NIK or IKKα. The importance of these inhibitors lies in their potential to dissect the precise roles of p52 in cellular processes, helping to untangle the web of signaling events it is involved in. By applying NFκB p52 inhibitors in experimental models, researchers can gain insights into the specific genes regulated by p52, its interactions with other proteins, and its broader impact on cellular behavior. Such studies bolster our comprehension of this complex and versatile transcription factor family and its many roles in cellular function and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit the activation of NFκB by preventing the degradation of IκB, thus keeping NFκB p52 in its inactive form in the cytoplasm. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
This compound inhibits the phosphorylation and subsequent degradation of IκB, blocking NFκB activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol inhibits the activation of NFκB by various mechanisms, including the inhibition of IκB kinase. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, can inhibit NFκB activation by blocking IκB kinase activity. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide inhibits NFκB by preventing IκB degradation. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $103.00 $210.00 $6132.00 | 2 | |
Emodin can block the activation of NFκB by preventing IκB degradation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is known to suppress NFκB activation by inhibiting IκB kinase activity. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
This compound can inhibit NFκB activation by blocking the phosphorylation and degradation of IκB. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
CAPE, found in bee propolis, inhibits NFκB by directly targeting the NFκB activation pathway. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
PDTC acts as an antioxidant and can suppress the activation of NFκB. | ||||||