NFκB p52 Inhibitors

Common NFκB p52 Inhibitors include, but are not limited to Curcumin CAS 458-37-7, BAY 11-7082 CAS 19542-67-7, Resveratrol CAS 501-36-0, D,L-Sulforaphane CAS 4478-93-7 and (-)-Epigallocatechin Gallate CAS 989-51-5.

Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) represents a family of transcription factors playing a central role in regulating various cellular processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis, and apoptosis. The NFκB family consists of several members, including RelA (p65), RelB, c-Rel, p50 (NFκB1), and p52 (NFκB2). Among these, p52 is an essential component, often forming heterodimers with other family members like RelB to regulate specific gene sets. The p52 protein is generated from the proteolytic processing of its precursor p100, and this conversion is a crucial step for the activation of the non-canonical NFκB pathway. This pathway is unique in its reliance on the NFκB-inducing kinase (NIK) and subsequent activation of the IκB kinase alpha (IKKα), leading to p100 processing to p52.

NFκB p52 inhibitors are molecules designed to specifically target and modulate the activity or levels of the p52 component of the NFκB family. Their mode of action may involve direct interaction with the p52 protein or by impeding its generation from its precursor p100. Furthermore, these inhibitors might target upstream signaling events leading to p52 activation, such as the interference with NIK or IKKα. The importance of these inhibitors lies in their potential to dissect the precise roles of p52 in cellular processes, helping to untangle the web of signaling events it is involved in. By applying NFκB p52 inhibitors in experimental models, researchers can gain insights into the specific genes regulated by p52, its interactions with other proteins, and its broader impact on cellular behavior. Such studies bolster our comprehension of this complex and versatile transcription factor family and its many roles in cellular function and homeostasis.