NF-E2 Activators
NF-E2 activators represent a diverse group of chemical compounds that enhance the activity of NF-E2, a transcription factor integral to various cellular processes, notably the antioxidant response and inflammation regulation. These activators primarily exert their effects through modulating upstream signaling pathways, particularly the Nrf2-Keap1-ARE pathway, thereby influencing NF-E2 activity. The underlying mechanisms of these activators demonstrate the intricate interplay of cellular signaling networks and the pivotal role of NF-E2 in maintaining cellular homeostasis. Tert-Butylhydroquinone (TBHQ), Oltipraz, Dimethyl Fumarate (DMF), Bardoxolone Methyl, and CDDO-Imidazolide exemplify compounds that activate NF-E2 through the Nrf2-Keap1 pathway. TBHQ disrupts the Nrf2-Keap1 interaction, facilitating Nrf2 nuclear translocation and subsequently enhancing NF-E2-mediated gene expression. Similarly, Oltipraz and DMF modulate this pathway by altering the cysteine residues of Keap1, leading to increased Nrf2 activity and, consequently, NF-E2 activation. Bardoxolone Methyl and CDDO-Imidazolide, synthetic derivatives, also target this interaction, promoting Nrf2 release and activation, thereby upregulating NF-E2-regulated genes involved in detoxification and oxidative stress response.
Other activators like Fumaric Acid and its derivatives, Andrographolide, Zinc, Ursolic Acid, Rosmarinic Acid, and Tocotrienols also modulate NF-E2 activity via the Nrf2 pathway. Fumaric Acid, through its esterified forms like DMF, enhances NF-E2 activity in regulating redox homeostasis genes. Andrographolide, a diterpenoid, induces Nrf2 nuclear translocation, amplifying NF-E2-mediated gene expression in antioxidant and anti-inflammatory pathways. Zinc's role in stabilizing Nrf2 and promoting its nuclear translocation underscores its indirect influence on NF-E2 activity. Ursolic Acid and Rosmarinic Acid, naturally occurring compounds, disrupt the Nrf2-Keap1 interaction, leading to increased NF-E2 activity in oxidative stress response and inflammation regulation. Tocotrienols, a form of vitamin E, enhance Nrf2 stabilization and nuclear translocation, thereby boosting NF-E2 target gene expression in cellular protection mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $66.00 | 4 | |
A synthetic antioxidant, TBHQ activates NF-E2 by inducing Nrf2 translocation to the nucleus. It disrupts the Nrf2-Keap1 interaction, promoting Nrf2 release and nuclear translocation, leading to enhanced NF-E2-mediated gene expression related to antioxidant responses. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz, a dithiolethione derivative, activates NF-E2 through the Nrf2-ARE pathway. By modifying Keap1 cysteines, it facilitates Nrf2 release and nuclear translocation, enhancing NF-E2-regulated gene expression, particularly in detoxification and antioxidant defense. | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $27.00 | 6 | |
DMF, a fumaric acid ester, activates NF-E2 by modulating the Nrf2 pathway. It induces the S-glutathionylation of Keap1, leading to Nrf2 stabilization and increased nuclear translocation, thus promoting NF-E2 target gene expression related to redox homeostasis and antioxidant defense. | ||||||
CDDO Methyl Ester | 218600-53-4 | sc-504720 | 10 mg | $220.00 | ||
A synthetic triterpenoid, CDDO Methyl Ester activates NF-E2 by disrupting the Keap1-Nrf2 interaction. It binds to cysteine residues on Keap1, promoting Nrf2 release and activation. | ||||||
CDDO Imidazolide | 443104-02-7 | sc-504719 | 1 mg | $700.00 | ||
A synthetic derivative of oleanolic acid, CDDO-Imidazolide activates NF-E2 through the Nrf2 pathway. It binds to Keap1, facilitating Nrf2 release and nuclear translocation, which enhances NF-E2 target gene expression involved in antioxidant and anti-inflammatory responses. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $42.00 $56.00 $112.00 $224.00 | ||
Fumaric Acid, a natural compound in the Krebs cycle, activates NF-E2 through its esterified derivatives like DMF. It modulates the Nrf2 pathway, leading to enhanced NF-E2 activity in the regulation of genes involved in redox homeostasis. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $39.00 | 7 | |
A labdane diterpenoid from Andrographis paniculata, Andrographolide activates NF-E2 through the Nrf2 pathway. It induces Nrf2 nuclear translocation, enhancing NF-E2-mediated gene expression in antioxidant and anti-inflammatory pathways. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc, an essential trace element, can indirectly activate NF-E2 by stabilizing Nrf2 and promoting its nuclear translocation. This activation enhances NF-E2-regulated gene expression, particularly in antioxidant defense mechanisms. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
A pentacyclic triterpenoid found in apple peels, Ursolic Acid activates NF-E2 by modulating the Nrf2-Keap1 pathway. It disrupts the interaction between Nrf2 and Keap1, leading to enhanced NF-E2 activity in regulating genes involved in oxidative stress response and inflammation. | ||||||
Rosmarinic Acid | 20283-92-5 | sc-202796 sc-202796A | 10 mg 50 mg | $57.00 $107.00 | 4 | |
A natural compound found in rosemary, Rosmarinic Acid activates NF-E2 by influencing the Nrf2-Keap1 pathway. It promotes Nrf2 nuclear translocation, enhancing NF-E2-regulated gene expression in antioxidant defense and cellular detoxification. | ||||||