NF-E2 Inhibitors
NF-E2 inhibitors encompass a diverse range of chemical compounds that modulate the activity of the NF-E2 protein, a transcription factor involved in various cellular processes, including antioxidant response and inflammation regulation. These inhibitors do not directly target NF-E2 but rather exert their effects through influencing upstream signaling pathways or related molecules, thereby indirectly altering NF-E2 activity. The molecular mechanisms by which these inhibitors function are multifaceted and often involve complex biochemical pathways. For instance, Curcumin and Sulforaphane modulate the Keap1-Nrf2-ARE pathway. Curcumin achieves this by modifying the cysteine residues of Keap1, disrupting its interaction with Nrf2 and thus influencing NF-E2-regulated gene expression. Sulforaphane, on the other hand, modifies Keap1 to facilitate Nrf2 release and nuclear translocation, impacting NF-E2 activity related to oxidative stress response genes.
Quercetin, Luteolin, and EGCG exert their modulatory effects through pathways like PI3K/Akt and MAPK. Quercetin inhibits PI3K and Akt, leading to reduced NF-kB activity, which is closely related to NF-E2, thus altering its transcriptional activity, especially in genes associated with cellular proliferation and survival. Luteolin's impact on NF-E2 is also mediated through its influence on these pathways, highlighting its role in modulating related gene expression. EGCG, a catechin, influences NF-E2 activity by affecting MAPK pathway components like ERK, JNK, and p38 MAPK, which are upstream regulators of NF-E2. Resveratrol and Caffeic Acid demonstrate their influence on NF-E2 through pathways such as SIRT1 and NF-kB, respectively. Resveratrol activates SIRT1, affecting NF-kB deacetylation and consequently modulating NF-E2 activity in genes related to inflammation and oxidative stress. Caffeic Acid inhibits NF-kB, altering NF-E2's transcriptional activity in similar gene sets. In summary, NF-E2 inhibitors represent a class of compounds that indirectly modulate NF-E2 activity through various biochemical pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A principal component of turmeric, Curcumin inhibits NF-E2-related pathways primarily through the Keap1-Nrf2-ARE pathway. It modulates Nrf2 activation, suppressing NF-E2-regulated gene expression. Curcumin alters cysteine residues on Keap1, affecting its interaction with Nrf2 and consequently NF-E2 activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Derived from cruciferous vegetables, Sulforaphane acts as an indirect NF-E2 inhibitor via the Nrf2-Keap1-ARE pathway. It modifies Keap1 cysteine residues, leading to Nrf2 release and nuclear translocation, thereby altering NF-E2-regulated gene expression related to oxidative stress. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid found in various plants, Quercetin modulates NF-E2 activity indirectly through the PI3K/Akt pathway. It inhibits PI3K and Akt, decreasing NF-kB activity, closely related to NF-E2, and thereby alters transcriptional activity of NF-E2 target genes, particularly those in cellular proliferation and survival. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Abundant in green tea, EGCG influences NF-E2 activity via the MAPK pathway. It modulates ERK, JNK, and p38 MAPK activities, upstream regulators of NF-E2, affecting NF-E2 activity, especially in stress response and antioxidant gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Found in grapes and berries, Resveratrol affects NF-E2 through the SIRT1 pathway. Activating SIRT1, it influences NF-kB deacetylation, modulating NF-E2 and altering transcriptional activity of NF-E2 target genes, especially in inflammation and oxidative stress response. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
An isoflavone in soy products, Genistein modulates NF-E2 by inhibiting tyrosine kinases, impacting various signaling pathways and NF-E2-regulated gene expression. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Derived from fruits like pomegranates, Ellagic Acid affects NF-E2 indirectly via the Nrf2 pathway. It promotes Keap1 degradation, enhancing Nrf2 nuclear translocation and activity, thus altering NF-E2 regulated gene expression, particularly in the antioxidant response. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $32.00 $62.00 | 1 | |
Found in various plants, Caffeic Acid influences NF-E2 through the NF-kB pathway. By inhibiting NF-kB, it modulates NF-E2 transcriptional activity, affecting genes involved in inflammatory responses and oxidative stress regulation. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Present in various plants, Luteolin modulates NF-E2 activity indirectly via the PI3K/Akt and MAPK pathways, affecting related gene expression. | ||||||