Molecular structure of Rosmarinic Acid, CAS Number: 20283-92-5
Rosmarinic Acid (CAS 20283-92-5)
See product citations (4)
Alternate Names:
(R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid
Application:
Rosmarinic Acid is an activator of GPR35
CAS Number:
20283-92-5
Purity:
≥98%
Molecular Weight:
360.31
Molecular Formula:
C18H16O8
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Rosmarinic Acid is a phenylpropanoid isolated from Labiatae herbs. The compound exhibits antiinflammatory activity and inhibits the proliferation of murine mesangial cells. Rosmarinic Acid may act to dose dependently inhibit migration, adhesion, and invasion of Ls174-T human colon carcinoma cells. Rosmarinic Acid has been documented to increase the melanin content in B16 melanoma cells through activation of protein kinase A. In the same study rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB) and activated cAMP response element (CRE). In the classical complement pathway Rosmarinic Acid inhibited C3-convertase. It also has shown to be an activator of GPR35.
Rosmarinic Acid (CAS 20283-92-5) References
- Inhibitory effects of rosmarinic acid on the proliferation of cultured murine mesangial cells. | Makino, T., et al. 2000. Nephrol Dial Transplant. 15: 1140-5. PMID: 10910436
- Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner. | Won, J., et al. 2003. Eur J Immunol. 33: 870-9. PMID: 12672052
- Rosmarinic acid induces melanogenesis through protein kinase A activation signaling. | Lee, J., et al. 2007. Biochem Pharmacol. 74: 960-8. PMID: 17651699
- Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. | Scheckel, KA., et al. 2008. J Nutr. 138: 2098-105. PMID: 18936204
- Rosmarinic acid sensitizes cell death through suppression of TNF-alpha-induced NF-kappaB activation and ROS generation in human leukemia U937 cells. | Moon, DO., et al. 2010. Cancer Lett. 288: 183-91. PMID: 19619938
- Anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in Ls174-T cells. | Xu, Y., et al. 2010. J Cell Biochem. 111: 370-9. PMID: 20506543
- Production and applications of rosmarinic acid and structurally related compounds. | Kim, GD., et al. 2015. Appl Microbiol Biotechnol. 99: 2083-92. PMID: 25620368
- Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation. | Jin, BR., et al. 2017. Sci Rep. 7: 46252. PMID: 28383063
- Rosmarinic Acid Mitigates Lipopolysaccharide-Induced Neuroinflammatory Responses through the Inhibition of TLR4 and CD14 Expression and NF-κB and NLRP3 Inflammasome Activation. | Wei, Y., et al. 2018. Inflammation. 41: 732-740. PMID: 29318480
- Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells. | Rong, H., et al. 2018. Free Radic Biol Med. 120: 114-123. PMID: 29555592
- Rosmarinic acid: a new inhibitor of complement C3-convertase with anti-inflammatory activity. | Englberger, W., et al. 1988. Int J Immunopharmacol. 10: 729-37. PMID: 3198307
- Rosmarinic acid improves boar sperm quality, antioxidant capacity and energy metabolism at 17°C via AMPK activation. | Feng, TY., et al. 2020. Reprod Domest Anim. 55: 1714-1724. PMID: 32969084
- Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway. | Nyandwi, JB., et al. 2020. Biochem Pharmacol. 182: 114246. PMID: 33011160
Inhibitor of:
AIM2, C8orf57, CBP β, group IIE sPLA2, nm23-M6, OST-PTP, Oxr1, PCNA, PCSK9, TARDBP, and TMPRSSs8.Activator of:
C1orf88, C3orf19_C130022K22Rik, cystatin C, Elastase-3B, Fn14, GPR35, H2-Q8, IL-28R, KIAA0090, NCX2, NF-E2, OR6N1, Rag C, Reg lllα, RNase T2, RTCD1, S-100 α chain, TGIF2LX2, TGR5, TRPV5, UGT8, Vitronectin, VSIG8, and ZFP319.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rosmarinic Acid, 10 mg | sc-202796 | 10 mg | $58.00 | |||
Rosmarinic Acid, 50 mg | sc-202796A | 50 mg | $109.00 |