NDUFAF6 Activators
NDUFAF6 activators are a group of chemical compounds that are specifically designed to enhance the activity of NDUFAF6, a mitochondrial assembly factor. NDUFAF6 is involved in the assembly and stabilization of complex I, a critical component of the mitochondrial respiratory chain responsible for the initial step of oxidative phosphorylation. The role of NDUFAF6 is essential for the proper function and maintenance of complex I, and the compounds in this class target the cellular pathways or direct interactions that can upregulate the function of NDUFAF6. The activation of NDUFAF6 by these compounds typically results in increased assembly and activity of complex I. Given the intricate nature of mitochondrial biochemistry, NDUFAF6 activators need to be carefully crafted to ensure specificity and efficacy in their action, often requiring the precise targeting of allosteric sites on the assembly factor or modulation of its expression levels.
The discovery and refinement of NDUFAF6 activators are highly specialized processes that rely on an in-depth understanding of mitochondrial biology and the structural nuances of the assembly factor itself. Advanced techniques such as cryo-electron microscopy or mass spectrometry-based proteomics may be employed to ascertain the three-dimensional structure and interaction partners of NDUFAF6, which is paramount in identifying potential activator binding sites. Once identified, these sites can be targeted through rational drug design, which enables the development of molecules that can bind with high specificity and affinity without affecting other mitochondrial proteins. These interactions often involve complex molecular forces, including hydrogen bonds, Van der Waals interactions, and electrostatic forces.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound found in the skin of grapes, might increase mitochondrial biogenesis by activating SIRT1, a protein that regulates mitochondrial function. This effect could potentially induce the expression of mitochondrial proteins such as NDUFAF6. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid found in a variety of fruits and vegetables, has been shown to modulate mitochondrial function and biogenesis through the activation of SIRT1 and PGC-1α pathways. These pathways may lead to upregulation of mitochondrial proteins including NDUFAF6. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
(-)-Epigallocatechin Gallate is a catechin found in green tea that may stimulate mitochondrial biogenesis via the activation of the PI3K/Akt pathway. This could potentially enhance the expression of mitochondrial assembly proteins like NDUFAF6. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural phenolic compound, may induce mitochondrial biogenesis by activating the PGC-1α/TFAM pathway. This pathway is key for the expression of mitochondrial proteins, potentially including NDUFAF6. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin, a biguanide derivative, has been shown to increase mitochondrial biogenesis through AMPK activation, which in turn can stimulate the expression of PGC-1α and mitochondrial proteins such as NDUFAF6. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine, a polyamine, is involved in regulating mitochondrial function through the activation of autophagy, a cellular process that could enhance mitochondrial biogenesis and potentially increase NDUFAF6 expression. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine, an isoquinoline alkaloid, may stimulate mitochondrial biogenesis through the activation of AMPK and PGC-1α pathways, potentially leading to an increase in mitochondrial proteins such as NDUFAF6. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane, a compound found in cruciferous vegetables like broccoli, is known to improve mitochondrial function by activating Nrf2, a protein that controls the expression of antioxidant proteins that protect against oxidative damage triggered by inflammation and injury, which could upregulate proteins like NDUFAF6. | ||||||
Pterostilbene, Pterocarpus marsupium | 537-42-8 | sc-203223 sc-203223A | 10 mg 100 mg | $207.00 $1173.00 | ||
Pterostilbene, a stilbene derivative similar to resveratrol, is involved in mitochondrial biogenesis via the activation of SIRT1. This could potentially enhance the expression of mitochondrial assembly proteins like NDUFAF6. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside, a form of vitamin B3, is involved in the production of NAD+, a key molecule for mitochondrial health. Increasing NAD+ levels could potentially upregulate mitochondrial proteins, including NDUFAF6. | ||||||