NDST Activators
N-Deacetylase/N-Sulfotransferase 1 (NDST1) is an integral enzyme in the biosynthesis of heparan sulfate (HS), a sulfated polysaccharide that is a major component of the extracellular matrix and cell surface. NDST1 is responsible for the initial modification steps of HS chains, which are essential for creating specific binding sites for a variety of proteins, including growth factors, morphogens, and adhesion molecules.
NDST1 enzymatically removes acetyl groups from N-acetylglucosamine residues in the HS precursor and adds sulfate groups to the resulting free amino groups. This dual activity is crucial for the subsequent pattern of sulfation that dictates the functional specificity of HS chains. The pattern of sulfation is a key determinant of the binding affinity of HS for various ligands, influencing a multitude of biological processes such as cell signaling, cell proliferation, angiogenesis, and wound healing.The expression of NDST1 is regulated by factors that control cellular differentiation and development. Aberrant expression or function of NDST1 is implicated in several pathological conditions, including cancer, where altered HS structure can affect tumor growth and metastasis.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
May upregulate NDST1 expression by modulating gene transcription during cell differentiation. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Could induce NDST1 expression through histone deacetylase inhibition and epigenetic changes. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Might increase NDST1 expression as a response to ER stress and unfolded protein response activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
May upregulate NDST1 by activating cAMP pathways and protein kinase A, affecting gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Could induce NDST1 through activation of protein kinase C and subsequent signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Might modulate NDST1 expression due to its role in cellular signaling and antioxidant properties. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
May induce NDST1 by causing DNA demethylation and gene expression changes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Could increase NDST1 expression through its role as a histone deacetylase inhibitor, altering chromatin structure. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Might upregulate NDST1 as part of the Wnt signaling pathway modulation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
May induce NDST1 as a cellular response to oxidative stress. | ||||||