NCDN inhibitors belong to a fascinating chemical class that has garnered significant attention and scientific interest in recent years. These inhibitors are compounds specifically designed and synthesized to target a protein called NCDN, which plays a vital role in various cellular processes. The acronym NCDN stands for neuronal calcium-binding protein and dendritic spine maturation factor, indicating its involvement in neuronal development and synaptic plasticity. NCDN inhibitors possess a unique molecular structure that allows them to interact with the active site of the NCDN protein. By binding to this active site, the inhibitors effectively hinder the normal function of NCDN and disrupt the associated signaling pathways and molecular cascades in which NCDN is involved. This interference at the molecular level offers researchers a valuable tool for investigating the intricate mechanisms underlying cellular processes regulated by NCDN.
The discovery and characterization of NCDN inhibitors have provided scientists with a means to explore the physiological consequences of inhibiting NCDN activity. Through comprehensive studies and meticulous experiments, researchers aim to unravel the precise molecular and physiological effects induced by NCDN inhibition. These investigations help elucidate the role of NCDN in various cellular contexts and shed light on its significance in neuronal development, synaptic plasticity, and other cellular processes. The chemical class of NCDN inhibitors represents a remarkable advancement in our understanding of cellular biology. Their specific and targeted action on NCDN provides scientists with an opportunity to explore the intricate interactions between this protein and other molecular components within cells. By deciphering the underlying molecular mechanisms associated with NCDN inhibition, researchers can gain valuable insights into fundamental cellular processes and pathways. Moreover, the availability of NCDN inhibitors opens up new avenues for experimental studies in scientific research. Researchers can utilize these inhibitors to manipulate NCDN activity and observe the resulting effects on cellular function and behavior. This knowledge can contribute to a deeper understanding of the fundamental principles governing cellular processes and pave the way for further discoveries in the field of molecular biology.
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Nome do Produto | CAS # | Numero de Catalogo | Quantidade | Preco | Uso e aplicacao | NOTAS |
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Donepezil | 120014-06-4 | sc-279006 | 10 mg | $73.00 | 3 | |
O inibidor da acetilcolinesterase, utilizado na doença de Alzheimer, melhora a neurotransmissão ao inibir a degradação da acetilcolina. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
O MLN4924 é um inibidor potente e seletivo da NAE que demonstrou atividade anticancerígena. Bloqueia a ativação do NEDD8 e interrompe a função das ligases Cullin-RING E3, levando à estabilização das suas proteínas de substrato e induzindo a paragem do ciclo celular e a apoptose nas células cancerígenas. | ||||||
MLN7243 | 1450833-55-2 | sc-507338 | 5 mg | $340.00 | ||
O TAK-243 é um inibidor de NAE de segunda geração desenvolvido como uma versão melhorada do MLN492. Apresenta uma maior potência e seletividade, com o potencial de ultrapassar certas limitações observadas com o MLN4924. | ||||||
Memantine hydrochloride | 41100-52-1 | sc-203628 | 50 mg | $68.00 | 4 | |
Antagonista dos receptores NMDA utilizado na doença de Alzheimer, modula a sinalização do glutamato para reduzir a excitotoxicidade. | ||||||
(S)-Rivastigmine | 123441-03-2 | sc-472567 | 500 mg | $300.00 | ||
Inibidor da acetilcolinesterase para a doença de Alzheimer, melhora a transmissão colinérgica. | ||||||
Galanthamine | 357-70-0 | sc-218556 | 10 mg | $320.00 | ||
Inibidor da acetilcolinesterase, modula igualmente os receptores nicotínicos para melhorar a função cognitiva na doença de Alzheimer. | ||||||
GSK 923295 | 1088965-37-0 | sc-490136 | 5 mg | $290.00 | ||
O GSK923295 é um inibidor seletivo da NAE que demonstrou atividade antitumoral em vários modelos de cancro. Inibe a enzima activadora NEDD8, conduzindo à acumulação de substratos da Cullin-RING E3 ligase e induzindo a paragem do ciclo celular e a apoptose. | ||||||
Levodopa | 59-92-7 | sc-205372 sc-205372A | 5 g 25 g | $53.00 $168.00 | 9 | |
Precursor da dopamina utilizado na doença de Parkinson, repõe os níveis de dopamina no cérebro. | ||||||
S(−)-Carbidopa | 28860-95-9 | sc-200749 sc-200749A | 25 mg 100 mg | $94.00 $270.00 | 5 | |
Aumenta a eficácia da L-DOPA, bloqueando a sua conversão em dopamina fora do cérebro. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $189.00 $209.00 $311.00 | 1 | |
Modula a sinalização do glutamato e pode retardar a progressão da doença na ELA (esclerose lateral amiotrófica). |