Molecular structure of Donepezil, CAS Number: 120014-06-4
Donepezil (CAS 120014-06-4)
See product citations (3)
Alternate Names:
Aricept
Application:
Donepezil is shown to increase levels of cortical acetylcholine
CAS Number:
120014-06-4
Purity:
≥99%
Molecular Weight:
379.50
Molecular Formula:
C24H29NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Donepezil is a noncompetitive AChE (acetylcholineesterase) inhibitor, which can readily cross the blood brain barrier and increase the concentration of cortical acetylcholine. It is known that Donepezil is a useful tool in the study of Alzheimer′s disease. Studies indicate that Donepezil protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil selectively inhibits acetylcholineesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies suggest that Donepezil increases the concentration of extracellular acetylcholine in the cerebral cortex and hippocampus of rats.
Donepezil (CAS 120014-06-4) References
- Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect. | Kawashiri, T., et al. 2019. J Pharmacol Sci. 140: 291-294. PMID: 31377017
- Donepezil-induced oligodendrocyte differentiation is mediated through estrogen receptors. | Imamura, O., et al. 2020. J Neurochem. 155: 494-507. PMID: 31778582
- Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation. | Jian, WX., et al. 2020. Acta Pharmacol Sin. 41: 588-598. PMID: 31913348
- Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature. | Silva, MA., et al. 2020. J Chem Inf Model. 60: 3463-3471. PMID: 32096991
- Evaluation of the neuroprotective effect of donepezil in type 2 diabetic rats. | Gomaa, AA., et al. 2021. Fundam Clin Pharmacol. 35: 97-112. PMID: 32602568
- Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy. | Perone, R., et al. 2021. ChemMedChem. 16: 187-198. PMID: 32716144
- Donepezil attenuated cardiac ischemia/reperfusion injury through balancing mitochondrial dynamics, mitophagy, and autophagy. | Khuanjing, T., et al. 2021. Transl Res. 230: 82-97. PMID: 33137536
- Donepezil attenuates the development of morphine tolerance in rats with cancer-induced bone pain: The role of cortical N-methyl-D-aspartate receptors. | Zhang, B., et al. 2021. Neurosci Lett. 747: 135678. PMID: 33516802
- Donepezil ameliorates oxygen-glucose deprivation/reoxygenation-induced brain microvascular endothelial cell dysfunction via the SIRT1/FOXO3a/NF-κB pathways. | Sun, X. and Liu, B. 2022. Bioengineered. 13: 7760-7770. PMID: 35286233
- Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction. | Li, M., et al. 2022. J Physiol Sci. 72: 12. PMID: 35725377
- Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle. | Redman, RR., et al. 2022. Br J Pharmacol. 179: 5273-5289. PMID: 36028305
- Donepezil. | Bryson, HM. and Benfield, P. 1997. Drugs Aging. 10: 234-9; discussion 240-1. PMID: 9108896
- Donepezil: an anticholinesterase inhibitor for Alzheimer's disease. | Shintani, EY. and Uchida, KM. 1997. Am J Health Syst Pharm. 54: 2805-10. PMID: 9428950
Inhibitor of:
AChE, AGPS, BChE, CapZ-β, CHAC1, CHT1, COLQ, CTRL, DMWD, Dnajc22, dNT-2, Doc 4, Dokl, Elmo3, ENGase, ERAB, ES, EXD, FIZ1, HRASLS, MOXD1, NCDN, NPAS3, NPW, Olfr305, Olfr826, Olr1591, Olr20, Olr239, Olr251, Olr32, PIMT, PRAT4B_Cnpy4, PRiMA, SEZ6, SIMP, SorCS1, Spatial, ST8Sia V, SUDD, tPA, and YadA.Activator of:
AChRα1, AChRα9, AChRδ, C6orf134, CPM, Ly-6F, Ly-6I, Lynx1, Npcd, Olfr1105, periaxin, RIC-3, SEZ6L2, and taperin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Donepezil, 10 mg | sc-279006 | 10 mg | $74.00 |