Galanthamine CAS: 357-70-0
MF: C17H21NO3
MW: 287.35
A selective acetylcholinesterase inhibitor.

Galanthamine (CAS 357-70-0)

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Alternate Names: (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofurol[3a,3,2,-ef][2]benzazepin-6-ol
Application: Galanthamine is a selective acetylcholinesterase inhibitor
CAS Number: 357-70-0
Purity: ≥96%
Molecular Weight: 287.35
Molecular Formula: C17H21NO3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Galanthamine is a selective AChE (acetylcholinesterase) inhibitor that blocks the breakdown of acetylcholine, allowing receptors to be activated for longer periods of time.


References

Bickel, U., et al.: Clin. Pharmacol. Ther., 50, 420 (1991) Maelicke, A., et al.: Drugs Dis Today, 1, 53 (1996) Sauvaltre, T., et al.: J. Med. Chem., 50, 5311 (2007)

Physical State :
Solid
Solubility :
Soluble in acetone, chloroform, ethanol (4 mg/ml), DMSO (10 mg/ml), and water (50 mM).
Storage :
Store at -20° C
Melting Point :
119-122° C
Boiling Point :
~439.3° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
Optical Activity :
α20/D -70.3°
IC50 :
Plasmodium falciparum: IC50 = 15.24 nM; AChE: IC50 = 100 nM (human); Cholinesterase: IC50 = 1.52 µM (Equus caballus); AChE: IC50 = 1.76 µM (rat); AChE: IC50 = 1.82 µM (Electrophorus electricus)
Ki Data :
AChE: Ki= 61.96 nM (human); BChE: Ki= 192.47 nM (human); Glutamate [NMDA] receptor subunit epsilon 2: Ki>0.1 mM (rat)
pK Values :
pKa: 13.93 (Predicted), pKb: 7.92 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
LW5952100
PubChem CID :
9651
MDL Number :
MFCD00867189
Beilstein Registry :
93736
SMILES :
CN1CC[[email protected]@]23C=C[[email protected]@H](C[[email protected]@H]2OC4=C(C=CC(=C34)C1)OC)O

Download SDS (MSDS)

Certificate of Analysis

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