Date published: 2025-9-21

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S(−)-Carbidopa (CAS 28860-95-9)

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Alternate Names:
(αS)-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic Acid; (−)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinamic Acid
Application:
S(−)-Carbidopa is a DDC inhibitor
CAS Number:
28860-95-9
Purity:
≥98%
Molecular Weight:
226.23
Molecular Formula:
C10H14N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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S(−)-Carbidopa is a compound that is extensively used in research applications focused on neurobiology and biochemistry. It serves as a tool for studying the metabolism of neurotransmitters, as it is known to inhibit the enzyme aromatic L-amino acid decarboxylase (AADC). By inhibiting AADC, S(−)-Carbidopa reduces the peripheral conversion of L-DOPA to dopamine, allowing researchers to investigate the central effects of L-DOPA without peripheral interference. This compound is also used in studies aimed at understanding the biochemistry of dopamine synthesis and its regulation within the central nervous system. Furthermore, S(−)-Carbidopa is instrumental in research exploring the mechanisms of action of enzyme inhibitors and their role in modulating neurotransmitter levels.


S(−)-Carbidopa (CAS 28860-95-9) References

  1. Intravenous l-DOPA plus carbidopa in depressed patients: average evoked response, learning, and behavioral changes.  |  Henry, GM., et al. 1976. Psychosom Med. 38: 95-105. PMID: 1273240
  2. Enantioselective metabolism of trans-4-hydroxy-2-nonenal by brain mitochondria.  |  Honzatko, A., et al. 2005. Free Radic Biol Med. 39: 913-24. PMID: 16140211
  3. Oxidation of carbidopa by tyrosinase and its effect on murine melanoma.  |  Gasowska-Bajger, B., et al. 2009. Bioorg Med Chem Lett. 19: 3507-10. PMID: 19457668
  4. Kinetic characterization of the oxidation of carbidopa and benserazide by tyrosinase and peroxidase.  |  Munoz-Munoz, JL., et al. 2009. Biosci Biotechnol Biochem. 73: 1308-13. PMID: 19502746
  5. The impact of levodopa on quality of life in patients with Parkinson disease.  |  Sethi, KD. 2010. Neurologist. 16: 76-83. PMID: 20220441
  6. The effects of carbidopa on the metabolism of 6-[18F]fluoro-L-dopa in rats, monkeys and humans.  |  Melega, WP., et al. 1990. Life Sci. 47: 149-57. PMID: 2117691
  7. Gas-phase acidity and dynamics of the protonation processes of carbidopa and levodopa. A QM/QD study.  |  Sukker, GM., et al. 2016. J Biomol Struct Dyn. 34: 2268-80. PMID: 26511889
  8. Delayed O-methylation of l-DOPA in MB-COMT-deficient mice after oral administration of l-DOPA and carbidopa.  |  Tammimäki, A., et al. 2018. Xenobiotica. 48: 325-331. PMID: 28375049
  9. Quantitation of levodopa and carbidopa in rat plasma by LC-MS/MS: The key role of ion-pairing reversed-phase chromatography.  |  Chi, J., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1054: 1-9. PMID: 28412665
  10. Carbidopa: a selective Ah receptor modulator (SAhRM).  |  Safe, S. 2017. Biochem J. 474: 3763-3765. PMID: 29109131
  11. The effects of carbidopa dose and time and route of administration on systemic L-dopa levels in rats.  |  Leppert, PS., et al. 1988. Pharm Res. 5: 587-91. PMID: 3247321
  12. The pharmacokinetic profile of carbidopa in dogs.  |  Obach, R., et al. 1984. J Pharm Pharmacol. 36: 415-6. PMID: 6146680
  13. The effect of carbidopa on the pharmacokinetics and metabolism of intravenously administered levodopa in blood plasma and skeletal muscle.  |  Deleu, D., et al. 1993. Naunyn Schmiedebergs Arch Pharmacol. 348: 576-81. PMID: 8133901
  14. Levodopa/carbidopa for childhood amblyopia.  |  Leguire, LE., et al. 1993. Invest Ophthalmol Vis Sci. 34: 3090-5. PMID: 8407216

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

S(−)-Carbidopa, 25 mg

sc-200749
25 mg
$94.00

S(−)-Carbidopa, 100 mg

sc-200749A
100 mg
$270.00