S(-)-Carbidopa CAS: 28860-95-9
MF: C10H14N2O4
MW: 226.23
A DDC inhibitor.

S(-)-Carbidopa (CAS 28860-95-9)

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Synonym: (αS)-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic Acid; (-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinamic Acid
Application: A DDC inhibitor
CAS Number: 28860-95-9
Purity: ≥98%
Molecular Weight: 226.23
Molecular Formula: C10H14N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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S(-)-Carbidopa is an inhibitor of DDC, the enzyme responsible for conversion of L-DOPA to dopamine. Administration of S(-)-Carbidopa with L-DOPA demonstrates a decrease in the effects associated with rapid conversion of L-DOPA to dopamine. S(-)-Carbidopa is also demonstrated to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.


References

1. Henry, G.M., et al. 1976. Psychosom Med. 38: 95-105. PMID: 1273240
2. Leguire, L.E., et al. 1993. Invest. Ophthalmol. Vis. Sci. 34: 3090-3095. PMID: 8407216
3. Deleu, D., et al. 1993. Naunyn Schmiedebergs Arch. Pharmacol. 348: 576-581. PMID: 8133901
4. Sethi, K.D. 2010. Neurologist. 16: 76-83. PMID: 20220441

Physical State :
Solid
Solubility :
Soluble in ethanol (10 mM), methanol (>3 mg/ml), 0.1N HCI (1 mg/ml), and water (1 mg/ml).
Storage :
Store at -20° C
Melting Point :
>181° C (dec.)
Boiling Point :
~528.7° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
pK Values :
pKa: 3.40
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MW5298000
PubChem CID :
34359
MDL Number :
MFCD00069231
EC Number :
249-271-9
Beilstein Registry :
657532
SMILES :
C[[email protected]](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN

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Certificate of Analysis

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S(-)-Carbidopa  Product Citations

See how others have used S(-)-Carbidopa. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 20305599  Georgiev, D. et al. 2010. Psychiatr Danub. 22: 94-98.

PMID: # 7618310  Anouti, A. et al. 1995. West. J. Med. 162: 510-513.

PMID: # 8417137  Kaakkola, S. et al. 1993. J. Neurochem. 60: 137-144.

PMID: # 2775615  Robertson, DR. et al. 1989. Br J Clin Pharmacol. 28: 61-69.

PMID: # 1105500  Critchley, E. et al. 1975. Postgrad Med J. 51: 619-621.

Citations 1 to 5 of 5 total
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