NCDN Antibody (B-3): sc-398686

NCDN Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects NCDN protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-NCDN antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NCDN protein, also known as neurochondrin, is a 729 amino acid leucine-rich cytoplasmic protein that plays a crucial role in nervous system signal transduction and is essential for spatial learning. NCDN functions as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 phosphorylation, which is vital for various signaling pathways in neurons. Additionally, NCDN is known to interact with melanin-concentrating hormone receptor 1, potentially modulating its activity and influencing processes such as bone metabolism, neurite outgrowth, and chondrocyte differentiation. NCDN is predominantly expressed in the adult brain and spinal cord, with lower levels found in the fetal brain, ovary, and testis, and is encoded by a gene located on human chromosome 1p34.3 and mouse chromosome 4 D2.2. NCDN (B-3) antibody is an invaluable tool for researchers studying the intricate roles of neurochondrin in neuronal function and development.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

NCDN Antibody (B-3) References:

1. Molecular cloning and expression of human neurochondrin-1 and -2.  |  Mochizuki, R., et al. 1999. Biochim Biophys Acta. 1446: 397-402. PMID: 10524216
2. Corrigendum to 'Molecular cloning and expression of human neurochondrin-1 and -2'(1).  |  Mochizuki, R., et al. 2000. Biochim Biophys Acta. 1490: 367-8. PMID: 10684983
3. Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality.  |  Mochizuki, R., et al. 2003. Biochem Biophys Res Commun. 310: 1219-26. PMID: 14559245
4. Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors.  |  Droucheau, E., et al. 2004. Biochim Biophys Acta. 1697: 181-96. PMID: 15023360
5. Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure.  |  Dateki, M., et al. 2005. J Biol Chem. 280: 20503-8. PMID: 15790563
6. Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling.  |  Wang, H., et al. 2009. Science. 326: 1554-7. PMID: 20007903
7. The +Gz recovery of consciousness curve.  |  Whinnery, T., et al. 2014. Extrem Physiol Med. 3: 9. PMID: 24843787
8. Targeted and non-targeted metabolite identification of MAM-2201 in human, mouse, and rat hepatocytes.  |  Kim, JH., et al. 2018. Drug Test Anal.. PMID: 29608249
9. The acquisition and generalization of fear of touch.  |  Biggs, EE., et al. 2020. Scand J Pain. 20: 809-819. PMID: 32712594
10. The Effect of Acute and Sustained Pain on Corticomotor Excitability: A Systematic Review and Meta-Analysis of Group and Individual Level Data.  |  Chowdhury, NS., et al. 2022. J Pain. 23: 1680-1696. PMID: 35605763
11. HER2 Status Assessment in Endometrial Serous Carcinoma: Comparative Analysis of Two Proposed Testing and Interpretation Algorithms.  |  Hashem, S., et al. 2024. Int J Gynecol Pathol. 43: 4-14. PMID: 37406350
12. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.  |  Nagase, T., et al. 1998. DNA Res. 5: 31-9. PMID: 9628581

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NCDN Antibody (B-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-NCDN Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NCDN Antibody (B-3) Specifications

Alternate Product Name: NCDN

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 17-43

Epitope Target: NCDN

Epitope Species: human

Product Reactivity/Detection: NCDN

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for NCDN Antibody (B-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin