Memantine hydrochloride (CAS 41100-52-1)
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Memantine hydrochloride is a medication utilized to treat Alzheimer′s disease and other types of dementia. Acting as a low-affinity, uncompetitive antagonist of NMDA receptors, this drug effectively alleviates symptoms associated with these conditions. It has undergone successful clinical trials and is currently accessible in numerous countries. Memantine hydrochloride functions by binding to NMDA receptors, impeding the influx of calcium ions into the cell. Consequently, it mitigates the harmful effects of excitotoxicity related to Alzheimer′s disease and other forms of dementia. Moreover, studies have demonstrated that memantine hydrochloride reduces amyloid-beta peptide levels in the brain, a substance implicated in the development of Alzheimer′s disease. Additionally, it has shown efficacy in diminishing the levels of inflammatory cytokines like tumor necrosis factor-alpha and interleukin-6, which are also associated with the pathogenesis of Alzheimer′s disease.
Memantine hydrochloride (CAS 41100-52-1) References
- Efficacy of memantine hydrochloride once-daily in Alzheimer's disease. | Kurz, A. and Grimmer, T. 2014. Expert Opin Pharmacother. 15: 1955-60. PMID: 25085661
- Efficacy of Memantine Hydrochloride in Neuropathic Pain. | Nair, AS. and Sahoo, RK. 2019. Indian J Palliat Care. 25: 161-162. PMID: 30820121
- Effect of memantine hydrochloride on cisplatin-induced neurobehavioral toxicity in mice. | Salih, NA. and Al-Baggou, BK. 2020. Acta Neurol Belg. 120: 71-82. PMID: 31190140
- A new spectrofluorimetric assay for quantification of Amisulpride and Memantine hydrochloride in real human plasma sample and pharmaceutical formulations via Hantzsch reaction. | Atia, NN., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 224: 117388. PMID: 31357052
- Utility of chromogenic property of 2, 2-dihydroxyindane-1, 3-dione for quantification of Memantine hydrochloride in pure, pharmaceutical preparation and application to uniformity testing. | Atia, NN., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 227: 117640. PMID: 31675657
- A rapid FTIR spectroscopic assay for quantitative determination of Memantine hydrochloride and Amisulpride in human plasma and pharmaceutical formulations. | Atia, NN., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 236: 118377. PMID: 32330826
- Development of a novel, fast, simple, nonderivative HPLC method with direct UV measurement for quantification of memantine hydrochloride in tablets. | Piponski, M., et al. 2020. J Sep Sci. 43: 3482-3490. PMID: 32627964
- Simple Two-step Procedure for the Synthesis of Memantine Hydrochloride from 1,3-Dimethyl-adamantane. | Vu, BD., et al. 2020. ACS Omega. 5: 16085-16088. PMID: 32656430
- Correction to 'Simple Two-step Procedure for the Synthesis of Memantine Hydrochloride from 1,3-Dimethyl-adamantane'. | Vu, BD., et al. 2020. ACS Omega. 5: 26295. PMID: 33073157
- Memantine hydrochloride: a drug to be repurposed against Chikungunya virus? | Pereira, AKDS., et al. 2021. Pharmacol Rep. 73: 954-961. PMID: 33523405
- Cerebralcare Granule® enhances memantine hydrochloride efficacy in APP/PS1 mice by ameliorating amyloid pathology and cognitive functions. | Qiao, O., et al. 2021. Chin Med. 16: 47. PMID: 34183022
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Memantine hydrochloride, 50 mg | sc-203628 | 50 mg | $68.00 |