NBPF10 Activators
NBPF10 Activators consist of diverse chemical compounds that indirectly enhance the functional activity of NBPF10 through modulation of various signaling pathways integral to neurodevelopment and cellular processes. Forskolin, by increasing cAMP levels, activates PKA, which may phosphorylate proteins within pathways that NBPF10 is a part of, thereby promoting its activity. Similarly, ionomycin raises intracellular calcium levels, potentially triggering calcium-dependent signaling that could influence NBPF10's role in neurodevelopmental processes. PMA, an activator of PKC, modifies multiple signaling cascades which could lead to the phosphorylation of substrates that interact with or regulate NBPF10. LY294002 and PD98059, through inhibiting PI3K and MEK respectively, alter the dynamics of the PI3K/AKT and MAPK/ERK pathways, pathways that NBPF10 might be associated with, thereby potentially enhancing NBPF10's functional role. SB203580's inhibition of p38 MAPK might similarly favor NBPF10's activity if NBPF10 operates downstream of p38 in stress response signaling.
Additionally, KN-93's inhibition of CaMKII and EGCG's broad kinase inhibitory effects could modulate calcium signaling networks and various other pathways that intersect with NBPF10's function, enhancing its activity, particularly in neuronal signaling. Sphingosine-1-phosphate, through sphingolipid signaling, could activate kinases and pathways that include NBPF10, enhancing processes such as neurogenesis or neural survival. Retinoic acid, known for its role in neural differentiation, might enhance NBPF10 activity if involved in retinoic acid-regulated pathways. The HSP90 inhibitor, 17-AAG, could increase NBPF10's functionality by influencing the stability or activity of NBPF10 via HSP90-associated chaperone complexes. Lastly, CPA, by activating adenosine A1 receptors, could modulate adenylate cyclase activity and downstream signaling, offering another potential route for enhancing NBPF10's activity if it plays a role in adenosine-regulated pathways. Collectively, these activators influence a complex network of signaling that converges on the enhancement of NBPF10's functional activity without the need for direct activation or upregulation of expression.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which activates PKA. PKA can phosphorylate various proteins that may be part of signaling pathways NBPF10 is involved in, potentially leading to enhanced functional activity of NBPF10 through phosphorylation events. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, influencing calcium-dependent signaling pathways. NBPF10's activity may be enhanced by calcium signaling, which is crucial in many cellular processes, including neurodevelopmental pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in various signaling cascades. PKC activation can indirectly enhance NBPF10 activity by modulating signaling pathways where NBPF10 participates or interacts with PKC-phosphorylated substrates. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that alters the PI3K/AKT pathway. Inhibition of PI3K could shift signaling dynamics in a way that indirectly enhances the functional activity of NBPF10 if NBPF10 is linked to this pathway or its downstream effects. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of MEK, which works upstream in the MAPK/ERK pathway. By inhibiting MEK, the pathway dynamics could be altered in a way that indirectly enhances the functional activity of NBPF10 if it is part of or affected by this cascade. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38, this compound could indirectly enhance NBPF10 activity if NBPF10 is regulated by or associated with pathways downstream of p38 MAPK, such as stress response pathways. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is an inhibitor of CaMKII (calcium/calmodulin-dependent protein kinase II). Inhibition of CaMKII may enhance NBPF10 activity by affecting calcium signaling networks that NBPF10 may influence or be regulated by. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG acts as a kinase inhibitor and has a broad range of effects on signaling pathways. It may enhance NBPF10 activity by modulating pathways that intersect with NBPF10's function, particularly in neuronal development and signaling. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is involved in sphingolipid signaling and can activate various kinases and downstream pathways. Enhancement of NBPF10 activity might occur if NBPF10 is part of signaling pathways influenced by S1P, such as those involved in neurogenesis or neural survival. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences gene expression by activating nuclear receptors. NBPF10 activity could be enhanced if NBPF10 is implicated in pathways regulated by retinoic acid, which is known to play a role in neural differentiation and development. | ||||||