NAT-16 Activators
NAT-16 activators belong to a specialized class of chemicals that are characterized by their ability to modulate the activity of a specific biochemical pathway involving a protein known as NAT-16. The NAT-16 protein is a part of a larger family of proteins that play crucial roles in various biological processes at the cellular level. The activators are designed to interact with this protein in a way that enhances its natural function. The chemical structure of NAT-16 activators is often complex, featuring a variety of functional groups that enable tight and specific binding to their target. This specificity is crucial as it determines the efficacy and selectivity of the activator for the NAT-16 protein over other proteins.
The design and synthesis of NAT-16 activators involve intricate organic chemistry techniques to ensure that the molecules are able to engage with the NAT-16 protein in the desired manner. These compounds generally operate at the molecular level, where they may influence the conformation of the NAT-16 protein, potentially altering its activity profile. The activators may bind to the active site of the protein, or to allosteric sites – regions of the protein outside of the active site that can influence the protein's function when molecules bind to them. The binding of NAT-16 activators to these sites can result in a change in the protein's shape and dynamics, which can subsequently affect the rate at which the protein carries out its normal biological functions. The study of NAT-16 activators thus involves a deep understanding of protein chemistry, structural biology, and molecular interactions, as scientists seek to elucidate the exact mechanisms by which these compounds exert their effects on the NAT-16 protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to phosphorylation of proteins that may be involved in the same pathways as NAT-16 or directly phosphorylate NAT-16, thereby enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to modulate kinase activity and could indirectly enhance NAT-16 activity by inhibiting kinases that negatively regulate pathways involving NAT-16, thus reducing their inhibitory effects. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a signaling lipid that activates sphingosine-1-phosphate receptors and can lead to downstream signaling events. This may include the activation of pathways that NAT-16 is a part of, potentially increasing the protein's functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent proteins and signaling pathways that could enhance the activity of NAT-16 if it is regulated by calcium-dependent mechanisms. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways. By mimicking cAMP, it activates PKA, which could phosphorylate downstream targets involved in the activation of NAT-16. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP production, leading to PKA activation. PKA then could enhance NAT-16 activity by phosphorylating proteins within its signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is another cAMP analog that diffuses into cells and activates PKA. PKA activation may lead to the enhancement of NAT-16 functional activity through phosphorylation of associated proteins. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, similar to ionomycin. This increase in calcium can activate calcium-dependent signaling pathways that may augment the activity of NAT-16. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
DiC8 is a synthetic analog of diacylglycerol (DAG) and acts as a PKC activator. By activating PKC, it could indirectly enhance the functional activity of NAT-16 through PKC-mediated signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can also activate stress-activated protein kinases (SAPKs). Activation of SAPKs may influence the activity of NAT-16 if it is part of the SAPK-regulated signaling pathways. | ||||||