NAT-16 Inhibitors
NAT-16 Inhibitors refers to a specific class of chemical compounds that act as inhibitors targeting the N-acetyltransferase 16 enzyme. This enzyme, often abbreviated as NAT-16, plays a crucial role in cellular processes related to acetylation, where an acetyl group is transferred to various substrates. The inhibition of NAT-16 is a strategic approach in modulating acetylation reactions, as it regulates the transfer of acetyl groups to specific biomolecules. Understanding the structural and biochemical characteristics of NAT-16 is essential for the development and design of inhibitors within this chemical class.
NAT-16 Inhibitors typically exhibit a high degree of specificity for the NAT-16 enzyme, showcasing selectivity in their interaction with the target. Researchers in the field focus on elucidating the molecular mechanisms by which these inhibitors bind to NAT-16 and interfere with its enzymatic activity. The structural information comes from studying NAT-16 Inhibitors aids in the rational design of novel compounds with improved potency and selectivity. This class of inhibitors holds promise for advancing our understanding of acetylation processes at the molecular level, contributing to the broader field of enzymology and biochemistry.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $69.00 $110.00 | 4 | |
Methimazole acts as a thyroid peroxidase inhibitor, affecting thyroid hormone synthesis. NAT-16 activity could be impacted indirectly due to altered metabolism and hormonal balance that influence acetylation processes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Sodium valproate is a histone deacetylase inhibitor. While it generally facilitates acetylation, its impact on chromatin structure could indirectly affect NAT-16 gene expression and thus its protein function. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase. This can lead to altered prostaglandin levels, which may indirectly affect NAT-16 by influencing cellular acetylation patterns. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is an antipsychotic drug that blocks dopamine and other receptors, potentially modifying neurotransmitter levels and indirectly influencing NAT-16 related acetylation processes. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram inhibits acetaldehyde dehydrogenase. By altering acetaldehyde metabolism, it may affect cellular acetyl-CoA levels, thereby having an indirect impact on NAT-16 acetyltransferase activity. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $44.00 $113.00 | 2 | |
Clioquinol chelates metals and inhibits metalloenzymes. This can affect the metal cofactor-dependent enzymes, potentially leading to changes in cellular pathways that indirectly impact NAT-16 activity. | ||||||
Amiodarone | 1951-25-3 | sc-480089 | 5 g | $312.00 | ||
Amiodarone affects thyroid hormone metabolism through inhibition of deiodinases. As thyroid hormones regulate metabolic processes, this could indirectly influence NAT-16's role in acetylation. | ||||||
Reserpine | 50-55-5 | sc-203370 sc-203370A | 1 g 5 g | $134.00 $406.00 | 1 | |
Reserpine irreversibly blocks the vesicular monoamine transporter, affecting neurotransmitter storage and potentially altering cellular pathways that NAT-16 may be involved in. | ||||||