Molecular structure of Amiodarone, CAS Number: 1951-25-3
Amiodarone (CAS 1951-25-3)
Alternate Names:
Ancaron; Sedacoron
CAS Number:
1951-25-3
Molecular Weight:
645.31
Molecular Formula:
C25H29I2NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Amiodarone is widely used in research for its impact on ion channels, particularly potassium and calcium channels, which has implications for understanding cardiac electrophysiology. Studies often utilize this compound to investigate its ion channel blocking effects on cardiac myocytes, which can provide insights into the mechanisms of arrhythmogenesis. Amiodarone′s influence on the metabolism and function of thyroid hormones is also a subject of interest, due to its structural similarity to thyroid hormones. Additionally, its lipophilic nature and prolonged half-life are key points of investigation in research on chemical disposition and the effects of chronic exposure.
Amiodarone (CAS 1951-25-3) References
- Amiodarone-induced T-U fusion. | Omar, HR. 2012. Am J Emerg Med. 30: 2081.e1-2. PMID: 22205017
- Amiodarone-induced lupus-like syndrome. | Yachoui, R. and Saad, W. 2015. Am J Ther. 22: e20-1. PMID: 23846521
- Amiodarone inhibits apamin-sensitive potassium currents. | Turker, I., et al. 2013. PLoS One. 8: e70450. PMID: 23922993
- Amiodarone-related thyroid dysfunction. | Hudzik, B. and Zubelewicz-Szkodzinska, B. 2014. Intern Emerg Med. 9: 829-39. PMID: 25348560
- Phlebitis in Intravenous Amiodarone Administration: Incidence and Contributing Factors. | Oragano, CA., et al. 2019. Crit Care Nurse. 39: e1-e12. PMID: 30710042
- Amiodarone for prevention of atrial fibrillation following esophagectomy. | Tisdale, JE., et al. 2019. J Thorac Cardiovasc Surg. 158: 301-310.e1. PMID: 30853230
- Time-to-onset analysis of amiodarone-associated thyroid dysfunction. | Kinoshita, S., et al. 2020. J Clin Pharm Ther. 45: 65-71. PMID: 31400296
- Amiodarone induced 'Blue man syndrome'; an unusual presentation. | Fishman, TJ., et al. 2020. Heart Lung. 49: 202-203. PMID: 31780190
- The Rationale for Use of Amiodarone and its Derivatives for the Treatment of Chagas' Disease and Leishmaniasis. | Benaim, G., et al. 2021. Curr Pharm Des. 27: 1825-1833. PMID: 32988342
- Amiodarone and/or lidocaine for cardiac arrest: A Bayesian network meta-analysis. | Zhao, H., et al. 2020. Am J Emerg Med. 38: 2185-2193. PMID: 33071078
- Amiodarone Use Prior to Cardiac Transplant Impacts Early Post-Transplant Survival. | Allana, SS., et al. 2021. Cardiovasc Drugs Ther. 35: 33-40. PMID: 33074524
- Effects of amiodarone, amioder, and dronedarone on Trichomonas vaginalis. | de Souza, TG., et al. 2022. Parasitol Res. 121: 1761-1773. PMID: 35435511
- The effects of amiodarone in ovarian injury due to oxidative stress and inflammation caused by ischemia-reperfusion. | Topcu, A., et al. 2022. Immunopharmacol Immunotoxicol. 44: 1022-1031. PMID: 35838634
- Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage in Trypanosoma cruzi-infected cardiac cells. | Barbosa, JMC., et al. 2022. Front Cell Infect Microbiol. 12: 975931. PMID: 36093188
- Interaction of Amiodarone with Azoles Against Aspergillus Planktonic Cells and Biofilms in vitro. | Duan, Z., et al. 2022. Mycopathologia. 187: 517-526. PMID: 36219382
Inhibitor of:
αENaC, 1700095B22Rik, c-Erb-A α, c-Erb-A α-1, c-Erb-A α-2, c-Erb-A β-1, c-Erb-A β-2, C6orf192, CYB561D1, Cyclosporin A, CYP2B13, CYP2C18, Cyp2c44, CYP2C9, CYP2D10, CYP2D11, CYP2D26, CYP2D6, CYP2D9, CYP2J9, CYP2U1, Cyp3a13, Cyp3a18, Cyp3a25, DIO2, FAR2, FK-506, gp210, HCN1, HCN3, HCN4, HERG, Iodothyronine deiodinase (DIO), KALIG-1, KCNA (Voltage-gated potassium (Kv) channels), KCNE1L, KCNE3, KCNH3, KCNH4, KCNH5, KCNH6, KCNH7, KCNT1, KIR2.2, KIR2.6, KIR7.1, KVβ.1, KVβ.3, KV6.3, KV9.3, LAL, LAMP-5, LIMP II, MAC30, NAT-16, Olfr305, Olfr94, Olfr948, Olr1646, Olr211, Olr808, OPN1LW, SMPDL3A, SP-C, Spot 14, THIK-2, Thyroxine, TMEM117, TMEM150B, TMEM175, TRα, TRβ1, Triiodothyronine, Troponin I-C, TSHβ, UNC119B, VSV-G, and ZNF729.Activator of:
ACOT2, Cyp2c66, Ebola virus VP40, Flavivirus, KCNG1, KCNG2, KCNH7, KCNRG, KCNV1, KIR4.2, KV2.2, MCT14, TBG, Thyroglobulin, and Thyroxine.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amiodarone, 5 g | sc-480089 | 5 g | $312.00 |