NAT-11 Inhibitors
NAT-11 Inhibitors encompass a range of chemical compounds that interfere with the protein's role in maintaining the acetylation and deacetylation equilibrium within cells. Trichostatin A and Anacardic acid are two examples that disrupt the delicate balance of acetylation states by inhibiting deacetylase and acetyltransferase activities, respectively. Trichostatin A's ability to promote hyperacetylation can impede NAT-11's deacetylase function, while Anacardic acid competes with NAT-11 for the acetyl-CoA binding site, potentially reducing the ability of NAT-11 to acetylate its substrates effectively.
Other compounds, such as Garcinol and C646, target histone acetyltransferases (HATs) but can also indirectly affect NAT-11 activity. By inhibiting HATs, they may reduce the pool of acetylated proteins, limiting the substrates available for NAT-11 to act on. This could lead to a decrease in NAT-11's functional activity as it has fewer targets to deacetylate, altering the acetylation equilibrium.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that increases acetylation levels of histones, potentially disrupting the balance of acetylation and deacetylation that NAT-11 mediates. This interference could inhibit the normal enzymatic function of NAT-11 by promoting hyperacetylation of targets that NAT-11 would typically deacetylate. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic acid is another histone acetyltransferase inhibitor which can disrupt NAT-11 mediated acetylation by competing for the acetyl-CoA binding site, thereby reducing NAT-11’s ability to transfer acetyl groups to its substrate proteins. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $136.00 $492.00 | 13 | |
Garcinol inhibits p300 and other histone acetyltransferases. By blocking these HATs, garcinol could lead to a compensatory increase in deacetylation activity by NAT-11, which inadvertently reduces NAT-11's available substrate pool and its functional activity. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a selective p300/CPB histone acetyltransferase inhibitor. By preferentially inhibiting these HATs, C646 may induce a relative increase in NAT-11-mediated deacetylation, paradoxically reducing NAT-11 activity by depleting its substrate availability. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known to inhibit histone acetyltransferase. While it mainly targets other HATs, the general reduction in acetylation levels can indirectly inhibit NAT-11 by reducing the overall pool of acetylated substrates it can act upon. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG has been shown to inhibit the activity of certain HATs. By reducing the acetylation of histones and other proteins, EGCG can indirectly decrease the functional activity of NAT-11 by limiting its role in the dynamic acetylation-deacetylation equilibrium. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $37.00 $111.00 | 14 | |
Sirtinol is an inhibitor of sirtuin deacetylases, which can disrupt the normal deacetylation activity in cells. This can lead to an imbalance favoring acetylation, further reducing the functional role of NAT-11 in cellular acetylation homeostasis. | ||||||
Splitomicin | 5690-03-9 | sc-358701 | 5 mg | $47.00 | ||
Splitomicin is a specific inhibitor of the sirtuin family of deacetylases. By inhibiting sirtuin activity, splitomicin can indirectly lead to a decrease in NAT-11 activity by causing an accumulation of acetylated substrates, which NAT-11 would normally deacetylate. | ||||||
Salermide | 1105698-15-4 | sc-224276 sc-224276A | 5 mg 10 mg | $70.00 $105.00 | 3 | |
Salermide, a sirtuin inhibitor, could potentially lead to hyperacetylation of substrates, a state which NAT-11 would normally counteract by deacetylation. Persistent inhibition of sirtuins may therefore reduce the demand for NAT-11’s enzymatic activity. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Tenovin-6 is a small molecule that inhibits sirtuin activity. By preventing the deacetylation of proteins, it could indirectly inhibit NAT-11 by causing an accumulation of acetylated proteins, which could saturate NAT-11's capacity to deacetylate substrates. | ||||||