Salermide is a reverse amide with strong inhibitory effects on SIRT1 (Sirtuin 1) and SIRT2 (Sirtuin 2). SIRT1/2 both belong to the family of NAD+-dependent class III histone deacetylases and are shown to target protein 53, a cell cycle regulator. Salermide is shown to induce acetylation of p53 and cause cell apoptosis. Salermide also inhibits members of HDAC3 (class III HDACs).
1. Lara, E., et al. 2009. Oncogene. 28: 781-791. PMID: 19060927 2. Peck, B., et al. 2010. Mol. Cancer Ther. 9: 844-855. PMID: 20371709
Soluble in DMSO (100 mM), DMF (~30 mg/ml), and DMSO : PBS (pH 7.2)(1:2) (~0.25 mg/ml).
Thank you for your question. Salermide is supplied as a crystalline solid. A stock solution may be made by dissolving the salermide in an organic solvent purged with an inert gas. Salermide is soluble in organic solvents such as DMSO and dimethyl formamide. The solubility of salermide in these solvents is approximately 30 mg/ml.
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Peck et alPeck et al. (PubMed ID 20371709) found that the SIRT inhibitor, Salermide, induced cell death in breast carcinoma cell lines and p53-deficient mouse fibroblasts. -SCBT Publication Review
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