NAPE-PLD Inhibitors
NAPE-PLD inhibitors are a class of chemical compounds designed to target and modulate the activity of N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD). NAPE-PLD is an enzyme found in various tissues throughout the body, particularly in the brain and nervous system. It plays a key role in the synthesis of N-acylethanolamines (NAEs), which are lipid molecules involved in various cellular processes, including the regulation of pain, inflammation, and neurotransmission. Inhibitors of NAPE-PLD are developed to interact with this enzyme, disrupting its enzymatic activity and, consequently, affecting the levels of NAEs within the cell.
These inhibitors are typically small molecules or compounds designed to bind to NAPE-PLD, inhibiting its ability to catalyze the hydrolysis of NAPEs into NAEs. By interfering with this enzymatic reaction, NAPE-PLD inhibitors may impact the cellular signaling pathways and functions associated with NAEs. Research into NAPE-PLD inhibitors can provide valuable insights into lipid metabolism and its role in various physiological processes, offering a deeper understanding of the molecular mechanisms involved in pain perception, inflammation, and neurotransmission.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipase Inhibitor, THL | 96829-58-2 | sc-203108 | 50 mg | $51.00 | 7 | |
Tetrahydrolipstatin, an inhibitor of lipases, could theoretically affect NAPE-PLD expression by altering lipid metabolism pathways and potentially impacting the regulatory mechanisms of lipid-processing enzymes. | ||||||
Rimonabant | 168273-06-1 | sc-205491 sc-205491A | 5 mg 10 mg | $72.00 $160.00 | 15 | |
Rimonabant, a cannabinoid receptor antagonist, might influence NAPE-PLD expression indirectly by modulating the endocannabinoid system and affecting the feedback regulation of lipid signaling pathways. | ||||||
JZL184 | 1101854-58-3 | sc-224031 sc-224031A sc-224031B | 5 mg 10 mg 50 mg | $43.00 $82.00 $300.00 | ||
JZL184, an inhibitor of monoacylglycerol lipase, might influence NAPE-PLD expression by disrupting the balance of endocannabinoid signaling, potentially affecting regulatory pathways of NAE biosynthesis. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin, known to interact with pain receptors, might indirectly affect NAPE-PLD expression by modulating nociceptive pathways and potentially influencing lipid signaling related to pain regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, found in grapes and berries, is involved in the modulation of various signaling pathways. Its impact on NAPE-PLD expression could be through pathways related to cellular stress and metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, from turmeric, has various cellular targets and might influence NAPE-PLD expression by modulating inflammatory pathways and the activity of enzymes involved in lipid signaling. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a soy isoflavone, may impact NAPE-PLD expression by affecting various cellular signaling pathways, including those related to lipid metabolism and endocannabinoid signaling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, a compound found in cruciferous vegetables, might affect NAPE-PLD expression by modulating antioxidant response pathways and potentially influencing lipid metabolism pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG), a major component of green tea, could influence NAPE-PLD expression through its effects on cellular antioxidant responses and metabolic pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, could potentially affect NAPE-PLD expression by modulating cellular pathways involved in inflammation, stress response, and lipid signaling. | ||||||