Molecular structure of JZL184, CAS Number: 1101854-58-3
JZL184 (CAS 1101854-58-3)
Alternate Names:
4-Nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate
Application:
JZL184 is a strong and selective inhibitor of Monoglyceride Lipase
CAS Number:
1101854-58-3
Molecular Weight:
520.49
Molecular Formula:
C27H24N2O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JZL184 is a strong and selective inhibitor of Monoglyceride Lipase (monoacylglycerol lipase, MAGL). JZL184 displays IC50 values of 8 nM and 4 muM for inhibition of Monoglyceride Lipase and fatty acid amide hydrolase in murine brain membranes, respectively. JZL184 reduces Monoglyceride Lipase activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists in mice.
JZL184 (CAS 1101854-58-3) References
- Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. | Pan, B., et al. 2009. J Pharmacol Exp Ther. 331: 591-7. PMID: 19666749
- Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. | Chang, JW., et al. 2012. Chem Biol. 19: 579-88. PMID: 22542104
- The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model. | Ghosh, S., et al. 2013. Life Sci. 92: 498-505. PMID: 22749865
- Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. | Wise, LE., et al. 2012. ACS Chem Neurosci. 3: 369-78. PMID: 22860205
- Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597. | Crow, JA., et al. 2012. Biochem Pharmacol. 84: 1215-22. PMID: 22943979
- The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. | Kerr, DM., et al. 2013. Br J Pharmacol. 169: 808-19. PMID: 23043675
- JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. | Khasabova, IA., et al. 2014. Pharmacol Res. 90: 67-75. PMID: 25304184
- Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells. | Ma, M., et al. 2016. Mol Med Rep. 13: 2850-6. PMID: 26847687
- JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice. | Marino, S., et al. 2020. Calcif Tissue Int. 107: 72-85. PMID: 32285169
- JZL184 protects hippocampal neurons from oxygen-glucose deprivation-induced injury via activating Nrf2/ARE signaling pathway. | Xu, J., et al. 2021. Hum Exp Toxicol. 40: 1084-1094. PMID: 33375871
- The protective effect of JZL184 on ovarian ischemia reperfusion injury and ovarian reserve in rats. | Demir Çaltekin, M., et al. 2021. J Obstet Gynaecol Res. 47: 2692-2704. PMID: 34008304
- Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome. | Navarro-Romero, A., et al. 2022. Elife. 11: PMID: 36217821
- The monoacylglycerol lipase inhibitor, JZL184, has comparable effects to therapeutic hypothermia, attenuating global cerebral injury in a rat model of cardiac arrest. | Xu, J., et al. 2022. Biomed Pharmacother. 156: 113847. PMID: 36252353
Inhibitor of:
ABHD12B, ABHD13, ABHD14A, ABHD14B, ABHD4, AI747699, CNRIP1, EG13909, H2-Bl, LGI3, LIPK, mMGL, Monoglyceride Lipase, NAPE-PLD, PLRP2, SMPD5, and TGH-2.Activator of:
ABHD6, LASS4, mMGL, mMgl1, and MrgB3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JZL184, 5 mg | sc-224031 | 5 mg | $43.00 | |||
JZL184, 10 mg | sc-224031A | 10 mg | $82.00 | |||
JZL184, 50 mg | sc-224031B | 50 mg | $300.00 |