Na+ CP type XIα Inhibitors
Na+ CP type XIα inhibitors work primarily by affecting the sodium balance within cells, which is a key function of Na+ CP type XIα. Several of the listed chemicals, including Amiloride, Benzamil, and Triamterene, are ENaC blockers that disrupt sodium homeostasis, indirectly leading to decreased functional activity of Na+ CP type XIα.
Loop diuretics such as Furosemide, Bumetanide, Torasemide, and Ethacrynic Acid, as well as thiazide and thiazide-like diuretics such as Hydrochlorothiazide, Chlorthalidone, Metolazone, Indapamide, and Quinethazone, inhibit the Na-Cl or Na-K-2Cl symporters. These symporters, like the ENaC, are involved in maintaining sodium balance in cells, a function that Na+ CP type XIα is also directly involved in. Therefore, by inhibiting these symporters, these diuretics can disrupt sodium homeostasis, indirectly leading tothe functional inhibition of Na+ CP type XIα. The chemicals that target ENaC and the sodium symporters exert their effects by altering the sodium balance in cells, a process in which Na+ CP type XIα plays a significant role. ENaC inhibitors such as Amiloride, Benzamil, and Triamterene, block the ENaC channels, which work in tandem with Na+ CP type XIα. Consequently, their blockade disrupts the normal functioning of Na+ CP type XIα by altering the sodium balance within the cells. These inhibitors are therefore indirect inhibitors of Na+ CP type XIα.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $57.00 | 6 | |
Amiloride is an indirect inhibitor of Na+ CP type XIα by blocking epithelial sodium channels (ENaC), which work in conjunction with Na+ CP type XIα in maintaining sodium balance in cells. This inhibition disrupts sodium balance and can indirectly lead to decreased functional activity of Na+ CP type XIα. | ||||||
Benzamil•HCl | 161804-20-2 | sc-201070 | 50 mg | $195.00 | 1 | |
Benzamil is a potent ENaC blocker. By inhibiting ENaC, which functions closely with Na+ CP type XIα, Benzamil can indirectly affect the activity of Na+ CP type XIα, leading to its functional inhibition. | ||||||
Triamterene | 396-01-0 | sc-213103A sc-213103 | 1 g 5 g | $22.00 $54.00 | ||
Triamterene is another ENaC blocker. Its inhibition of ENaC disrupts the sodium balance managed by Na+ CP type XIα, which can indirectly lead to decreased functional activity of Na+ CP type XIα. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $55.00 $240.00 $333.00 $562.00 $988.00 | ||
Hydrochlorothiazide is a diuretic that inhibits the Na-Cl symporter in the distal convoluted tubule. This can disrupt the homeostasis of sodium balance that Na+ CP type XIα is involved in, indirectly leading to its functional inhibition. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
Furosemide is a loop diuretic that inhibits the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. This can indirectly lead to the functional inhibition of Na+ CP type XIα, which is involved in maintaining sodium balance. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Bumetanide is a loop diuretic that inhibits the Na-K-2Cl symporter. This inhibition can disrupt the sodium balance that Na+ CP type XIα helps maintain, thus indirectly inhibiting its functional activity. | ||||||
Torsemide | 56211-40-6 | sc-213059 | 10 mg | $260.00 | ||
Torasemide inhibits the Na-K-2Cl symporter. By disrupting the sodium balance that Na+ CP type XIα is involved in, Torasemide can indirectly lead to decreased functional activity of Na+ CP type XIα. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
Ethacrynic Acid is a loop diuretic that inhibits the Na-K-2Cl symporter. This can indirectly lead to the functional inhibition of Na+ CP type XIα, which helps maintain sodium balance. | ||||||
Chlorthalidone | 77-36-1 | sc-207427 | 25 mg | $243.00 | 1 | |
Chlorthalidone inhibits the Na-Cl symporter, disrupting the sodium balance that Na+ CP type XIα is involved in, thus indirectly leading to its functional inhibition. | ||||||
Metolazone | 17560-51-9 | sc-211900 | 100 mg | $228.00 | ||
Metolazone inhibits the Na-Cl symporter in the distal convoluted tubule. This can disrupt the homeostasis of sodium balance that Na+ CP type XIα is involved in, indirectly leading to its functional inhibition. | ||||||