Metolazone (CAS 17560-51-9)
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Metolazone is a compound of significance in the study of renal physiology and electrolyte balance. It is utilized in research to understand the mechanism of action on the distal convoluted tubules and the proximal part of the distal tubule in the kidneys. This compound helps in elucidating the processes involved in sodium and chloride reabsorption. Researchers use metolazone to explore electrolyte and fluid balance, as well as the regulation of these processes by the kidneys under various experimental conditions. Studies involving metolazone contribute to the fundamental knowledge of renal function and the body′s handling of electrolytes, which is essential for the understanding of fluid homeostasis. Additionally, the compound is of interest in the investigation of renal excretory response and the effect of diuretics on kidney function in physiological and experimental models.
Metolazone (CAS 17560-51-9) References
- Determination of metolazone in human blood by liquid chromatography with electrospray ionization tandem mass spectrometry. | Wei, G., et al. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 845: 169-73. PMID: 16908225
- The evaluation of the diuretic action of parenteral formulations of metolazone. | Cvetanovic, I., et al. 2007. Am J Ther. 14: 25-9. PMID: 17303972
- Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failure. | Ng, TM., et al. 2013. J Cardiovasc Pharmacol Ther. 18: 345-53. PMID: 23538300
- Simultaneous determination of metolazone and losartan potassium in their binary mixtures using high-performance liquid chromatography with fluorimetric detection: application to combined tablets and spiked human plasma. | Walash, MI., et al. 2014. Luminescence. 29: 462-70. PMID: 23996979
- Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1. | Banerjee, M. and Chen, T. 2014. Biochem Pharmacol. 92: 389-402. PMID: 25181459
- Simultaneous determination of metolazone and valsartan in plasma by on-line SPE coupled with liquid chromatography/tandem mass spectrometry. | Zhou, J., et al. 2017. Eur J Mass Spectrom (Chichester). 23: 305-312. PMID: 29028382
- Simultaneous determination of metolazone and losartan in their combined tablets using synchronous fluorescence spectroscopy. | Fathy, ME., et al. 2019. Luminescence. 34: 607-614. PMID: 31111664
- Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans. | Ito, A., et al. 2021. Biogerontology. 22: 119-131. PMID: 33216250
- Comparison of diuretic strategies in diuretic-resistant acute heart failure: a systematic review and network meta-analysis. | Orso, D., et al. 2021. Eur Rev Med Pharmacol Sci. 25: 2971-2980. PMID: 33877660
- First-order derivative synchronous spectrofluorimetric determination of two antihypertensive drugs, metolazone and valsartan, in pharmaceutical and biological matrices. | Zeid, AM., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 267: 120591. PMID: 34789407
- Formulation, Characterization, and the Diuretic Effects of a New Intravenous Metolazone Emulsion. | Ahlschwede, KM., et al. 2022. Drug Res (Stuttg). 72: 299-305. PMID: 35537450
- Metolazone Versus Intravenous Chlorothiazide for Decompensated Heart Failure Sequential Nephron Blockade: A Retrospective Cohort Study. | Cisowska, T., et al. 2022. J Card Fail. 28: 1367-1371. PMID: 35688407
- Metolazone therapy of active calcium nephrolithiasis. | Cunningham, E., et al. 1982. Clin Pharmacol Ther. 32: 642-5. PMID: 7128005
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Metolazone, 100 mg | sc-211900 | 100 mg | $228.00 |