Molecular structure of Amiloride • HCl, CAS Number: 2016-88-8
Amiloride • HCl (CAS 2016-88-8)
See product citations (6)
Alternate Names:
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Application:
Amiloride • HCl is a calcium channel and sodium channel protein inhibitor
CAS Number:
2016-88-8
Purity:
≥98%
Molecular Weight:
266.09
Molecular Formula:
C6H8ClN7O•HCl
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Amiloride hydrochloride is a selective T-type calcium channel protein inhibitor that may act to inhibit the Polycystin-L channel (Polycystic kidney disease 2-like 1 protein: PKD2L1), a member of the transient receptor potential (TRP) superfamily of cation channels, including the NHE (sodium/hydgrogen exchanger). Amiloride is also an epithelial sodium channel protein inhibitor, which inhibits sodium reabsorption without affecting potassium concentrations. Amiloride serves as a non-selective acid-sensing ion channel (ASIC) blocker and a selective inhibitor of uPA (urokinase plasminogen activator). Research shows that amiloride reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 muM. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein.
Amiloride • HCl (CAS 2016-88-8) References
- Molecular basis of specific inhibition of urokinase plasminogen activator by amiloride. | Jankun, J. and Skrzypczak-Jankun, E. 1999. Cancer Biochem Biophys. 17: 109-23. PMID: 10738907
- Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human. | Loffing, J. and Kaissling, B. 2003. Am J Physiol Renal Physiol. 284: F628-43. PMID: 12620920
- Inhibition of TRPP3 channel by amiloride and analogs. | Dai, XQ., et al. 2007. Mol Pharmacol. 72: 1576-85. PMID: 17804601
- Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway. | Cao, BY., et al. 2010. J Ethnopharmacol. 131: 122-9. PMID: 20558269
- Pharmacological profiles of the murine gastric and colonic H,K-ATPases. | Shao, J., et al. 2010. Biochim Biophys Acta. 1800: 906-11. PMID: 20594946
- Enhancement in fluorescence response by a quencher for amiloride upon binding to thymine opposite an abasic site in a DNA duplex. | Sato, Y., et al. 2010. Anal Chim Acta. 675: 49-52. PMID: 20708115
- The amiloride-sensitive sodium channel. | Sariban-Sohraby, S. and Benos, DJ. 1986. Am J Physiol. 250: C175-90. PMID: 2420186
- Amiloride selectively blocks the low threshold (T) calcium channel. | Tang, CM., et al. 1988. Science. 240: 213-5. PMID: 2451291
- Development and Validation of a Stability-Indicating Capillary Electrophoresis Method for the Determination of Zolpidem Tartrate in Tablet Dosage Form with Positive Confirmation using 2D- and 3D-DAD Fingerprints. | Al Azzam, KM., et al. 2014. Sci Pharm. 82: 341-56. PMID: 24959406
- Inhibitory effects of amiloride and its analogues on prostaglandin E2-stimulated fluid transport by cultured porcine thyroid cells: evidence for apical membrane Na+ channels. | Matainaho, T., et al. 1989. J Endocrinol. 123: 93-7. PMID: 2553844
- Amiloride and its analogs as tools in the study of ion transport. | Kleyman, TR. and Cragoe, EJ. 1988. J Membr Biol. 105: 1-21. PMID: 2852254
- Jet dispensing of multi-layered films for the co-delivery of three antihypertensive agents. | Scoutaris, N., et al. 2018. Drug Deliv Transl Res. 8: 32-42. PMID: 28967043
- Ion Transport Modulators as Antimycobacterial Agents. | Mitini-Nkhoma, SC., et al. 2020. Tuberc Res Treat. 2020: 3767915. PMID: 33294223
- Ion Transport Modulators Differentially Modulate Inflammatory Responses in THP-1-Derived Macrophages. | Mitini-Nkhoma, SC., et al. 2021. J Immunol Res. 2021: 8832586. PMID: 33928172
- New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme). | Macfie, HL., et al. 1981. Drug Intell Clin Pharm. 15: 94-8. PMID: 7274028
Inhibitor of:
δENaC, γENaC, 11β-HSD2, 3110007F17Rik, 4922502D21Rik, 4930428D18Rik, 4933425O20Rik, 5430405G05Rik, AE3, Aldosterone, Angiogenesis, AQP12A, AQP2, ATP13A3, ATPase, C20orf111, C4ST-2, C8orf5, Calcium Channel Protein, CAT-4, CatSperγ, Cdc50B, CL-P1, CNG-1, COMMD3, CTA, EG639396, EG668210, ENDOD1, FAM18B, FXYD7, GPR89B, HEAB, ILDR1, Like-Sm (LSm), LRRC8E, LTRPC7, Ly6/uPAR (LYNX; Ly6/neurotoxin), mKIAA0195, MMGT1, MrgA9, MrgB3, Na+ CP type XIα, Na+/K+-ATPase α1, Neurophysin I, NHE, NHE-3, NHE-4, NHE-5, NHE-7, NHE-9, NKAIN3, NKAIN4, NOP9, Olfr31, Olfr33, Olfr332, Olr1432, Olr34, Olr444, OR10AG1, OR10H5, OR4D10, OR52E5, OR5K4, OR8U9, OSR1, OTOP1, OTOP2, OTOP3, P5CRL, PEPT1, Polycystin-2, Polycystin-L, PQLC2, Prostasin, PRPF39, rBAT, SART-1, SFRS15, SLAM, SLC10A4, SLC5 (solute carrier family 5; SLC5A), SNAT3, Sodium Channel Protein, Sodium/Potassium-ATPase Protein, spectrin αII, STOML1, STOML3, TAS1R (taste receptor; GPCR), TAX-4, THEM92, TMEM143, TMEM150A, TMEM168, Tmem210, TMEM215, TMEM34, TMEM63B, TMEM86A, TMEM87B, TMIE, Trk1, Unc79, uPA, V1RB5, V1RI2, Vmn2r2, Vmn2r31, Vmn2r39, Vmn2r4, Vmn2r55, Vmn2r80, Vmn2r81, WNK1, WNK3, Xg, and ZNHIT2.Activator of:
1700030K09Rik, AQP0, ATP13A3, Chromozym t-PA, CLIC5, COTE1, Dynamin II, Eps15L1, GGTL3, hole, IFI-205, Kctd12b, Klkb21, KLKb8, Mesothelin, MON2, MRS2p, Na+ CP type Iα, Na+ CP type IIIα, Na+ CP type IIIβ, NCCT, NHEDC2, Nop56, OR11H1, OR2G6, OR4C45, ORCTL2, OTOP1, OTOP3, Pendrin, Pol II-H, POM121, RBMXL3, RNA pol α, RPA40, Rpp30, SFRS17A, Ski2, SLC-1, SLC10A5, SLC35E4, SLC45A4, SLC46A3, SLC4A7, Sodium Chloride, stefin A3, STON1, T-type calcium channel α1H, T-type calcium channel α1I, TFIIA-β, TMEM93, U2 snRNP A, and VPS37B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amiloride • HCl, 25 mg | sc-3578 | 25 mg | $22.00 | |||
Amiloride • HCl, 100 mg | sc-3578A | 100 mg | $56.00 |