Amiloride dot HCl CAS: 2016-88-8
MF: C6H8ClN7O•HCl
MW: 266.09
A calcium channel and sodium channel protein inhibitor.

Amiloride • HCl (CAS 2016-88-8)

Amiloride andbull HCl | CAS 2016-88-8 is rated 5.0 out of 5 by 2.
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Alternate Names: N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Application: Amiloride • HCl is a calcium channel and sodium channel protein inhibitor
CAS Number: 2016-88-8
Purity: ≥98%
Molecular Weight: 266.09
Molecular Formula: C6H8ClN7O•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Amiloride hydrochloride is a selective T-type calcium channel protein inhibitor that has been shown to inhibit the Polycystin-L channel (Polycystic kidney disease 2-like 1 protein: PKD2L1), a member of the transient receptor potential (TRP) superfamily of cation channels, including the NHE (sodium/hydgrogen exchanger). Amiloride is also an epithelial sodium channel protein inhibitor, which inhibits sodium reabsorption without affecting potassium concentrations. Amiloride serves as a non-selective acid-sensing ion channel (ASIC) blocker and a selective inhibitor of uPA (urokinase plasminogen activator). Research shows that amiloride reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein.


References

1. Macfie, H.L., et al. 1981. Drug Intell Clin Pharm. 15: 94-98. PMID: 7274028
2. Sariban-Sohraby, S., et al. 1986. Am. J. Physiol. 250: C175-C190. PMID: 2420186
3. Kleyman, T.R., et al. 1988. J. Membr. Biol. 105: 1-21. PMID: 2852254
4. Tang, C.M., et al. 1988. Science. 240: 213-215. PMID: 2451291
5. Matainaho, T., et al. 1989. J. Endocrinol. 123: 93-97. PMID: 2553844
6. Jankun, J., et al. 1999. Cancer Biochem. Biophys. 17: 109-123. PMID: 10738907
7. Loffing, J., et al. 2003. Am. J. Physiol. Renal Physiol. 284 F628-F643. PMID: 12620920
8. Dai, X.Q., et al. 2007. Mol. Pharmacol. 72: 1576-1585. PMID: 17804601
9. Sato, Y., et al. 2010. Anal Chim Acta. 675: 49-52. PMID: 20708115
10. Shao, J., et al. 2010. Biochim. Biophys. Acta. 1800: 906-911. PMID: 20594946
11. Cao, B.Y., et al. 2010. J Ethnopharmacol. 13: 122-129. PMID: 20558269

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), water (10 mM warm), and methanol. Insoluble in chloroform, and ethanol.
Storage :
Store at room temperature
Melting Point :
295-297° C (dec.)
Boiling Point :
628.1° C at 760 mmHg (Predicted)
IC50 :
epithelial tetrodotoxin insensitive Na+ channel: IC50 = 1 µM; Urokinase-type plasminogen activator: IC50 = 11 µM (human)
Ki Data :
Urokinase-type plasminogen activator: Ki= 7 µM (human)
pK Values :
pKa: 7.81 (Predicted), pKb: 3.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UQ2275500
PubChem CID :
16230
Merck Index :
14: 406
MDL Number :
MFCD00058197
EC Number :
217-958-2
Beilstein Registry :
4038903
SMILES :
C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl

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Certificate of Analysis

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Amiloride dot HCl (CAS 2016-88-8)  Product Citations

See how others have used Amiloride dot HCl (CAS 2016-88-8). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 19903858  Liu, JW. et al. 2009. Cancer Res. 69: 8662-8669.

PMID: # 15701794  Stolz, J. et al. 2005. Eukaryot Cell. 4(2): 319-326.

PMID: # 11953898  Weinmann, M. et al. 2002. Br J Cancer. 86(8): 1355-1361.

PMID: # 29920670  J. Periodont. Res. 53: 861-869.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Relevant assays for usage as analytical standards Relevant assays for usage as analytical standards.
Date published: 2015-06-08
Rated 5 out of 5 by from Liu Liu, et. al. (PubMed ID 19903858) used Amiloride to confirm the identity of the bands in the duplicate gels were that of uPA. -SCBT Publication Review
Date published: 2015-06-08
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