N-CoR Activators
The class of chemicals known as N-CoR activators comprises a group of compounds that modulate the activity of Nuclear Receptor Co-Repressor (N-CoR), a key player in transcriptional regulation. These activators exert their effects through various molecular mechanisms, influencing N-CoR stability and recruitment to target genes, ultimately leading to the repression of gene transcription and regulation of cellular processes. GW9662, an antagonist of PPARγ (Peroxisome Proliferator-Activated Receptor gamma), activates N-CoR by preventing the binding of PPARγ to N-CoR. This disruption enhances the formation of the N-CoR/PPARγ complex, leading to the repression of PPARγ target genes. Trichostatin A and SAHA (Vorinostat), HDAC inhibitors, activate N-CoR by preventing its deacetylation. This acetylation enhances N-CoR stability and promotes its association with transcriptional complexes, facilitating the repression of gene expression.
BIX01294, a G9a inhibitor, activates N-CoR by preventing H3K9 methylation. This inhibition enhances N-CoR recruitment to target genes, contributing to the transcriptional repression of specific genomic loci. JQ1 and XMD8-92, BET protein inhibitors, activate N-CoR by preventing their interaction with N-CoR. This inhibition enhances N-CoR recruitment to target genes, promoting transcriptional repression. MS-275, another HDAC inhibitor, activates N-CoR by preventing its deacetylation. This acetylation enhances N-CoR stability and promotes its association with transcriptional complexes, facilitating the repression of gene expression. The dual role of HDAC inhibitors like MS-275 in modulating N-CoR activity provides insights into epigenetic regulation. A-485, an inhibitor of p300/CBP, activates N-CoR by preventing its interaction with N-CoR. This inhibition enhances N-CoR recruitment to target genes, contributing to the repression of gene transcription. The intricate regulatory network involving p300/CBP and N-CoR, exemplified by A-485, highlights the fine-tuned control of transcriptional processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid activates N-CoR by binding to its receptor RAR, leading to the recruitment of N-CoR to target genes. This interaction promotes the repression of gene transcription, contributing to the regulation of cellular processes governed by N-CoR-mediated gene repression. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $70.00 | 30 | |
GW9662 activates N-CoR by inhibiting PPARγ, preventing its binding to N-CoR and promoting the formation of the N-CoR/PPARγ complex. This interaction enhances N-CoR-mediated transcriptional repression, influencing cellular processes regulated by N-CoR-associated pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A activates N-CoR by inhibiting HDACs, preventing N-CoR deacetylation. This acetylation enhances N-CoR stability, promoting its association with transcriptional complexes and facilitating the repression of gene expression, contributing to cellular processes regulated by N-CoR. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX01294 activates N-CoR by inhibiting G9a, preventing H3K9 methylation. This inhibition enhances N-CoR recruitment to target genes, promoting transcriptional repression and influencing cellular processes regulated by N-CoR-associated pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates N-CoR by inhibiting NF-κB, preventing its binding to N-CoR. This inhibition enhances N-CoR-mediated repression of NF-κB target genes, influencing cellular processes regulated by the NF-κB/N-CoR axis. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275 activates N-CoR by inhibiting HDACs, preventing N-CoR deacetylation. This acetylation enhances N-CoR stability, promoting its association with transcriptional complexes and facilitating the repression of gene expression, contributing to cellular processes regulated by N-CoR. | ||||||
XMD 8-92 (free base) | 1234480-50-2 | sc-364068 sc-364068A sc-364068B sc-364068C | 5 mg 10 mg 100 mg 1 g | $235.00 $340.00 $1700.00 $10330.00 | 10 | |
XMD8-92 activates N-CoR by inhibiting BRD4, preventing its interaction with N-CoR. This inhibition enhances N-CoR recruitment to target genes, promoting transcriptional repression and influencing cellular processes regulated by N-CoR-associated pathways. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
A-485 activates N-CoR by inhibiting p300/CBP, preventing its interaction with N-CoR. This inhibition enhances N-CoR recruitment to target genes, promoting transcriptional repression and influencing cellular processes regulated by N-CoR-associated pathways. | ||||||