Date published: 2025-11-24

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N-CoR Inhibitors

The chemical class known as N-CoR inhibitors encompasses a diverse array of compounds that intricately modulate the function of N-CoR (Nuclear Receptor Co-Repressor). Among these, Bexarotene stands out as a Retinoid X receptor (RXR) agonist, facilitating the dissociation of corepressor complexes from N-CoR. This action allows for the dynamic modulation of N-CoR's transcriptional regulatory role, impacting the expression of target genes. Histone deacetylase (HDAC) inhibitors such as SAHA (Vorinostat) and Entinostat contribute to this class by influencing N-CoR through altered histone acetylation. SAHA, in particular, affects the acetylation status of histones, indirectly impacting N-CoR and its corepressor complex formation. Additionally, Am580, a Retinoic acid receptor (RAR) agonist, modulates N-CoR by participating in retinoic acid receptor signaling pathways. These pathways play a crucial role in shaping the interaction dynamics of N-CoR within the cellular context.Niclosamide, acting as a STAT3 inhibitor, influences N-CoR through the JAK/STAT pathway, preventing N-CoR phosphorylation and promoting its transcriptional activity. DZNep, an S-adenosylhomocysteine hydrolase (SAHH) inhibitor, indirectly affects N-CoR through epigenetic modifications. The impact of p300/CBP histone acetyltransferase (HAT) inhibition by C646 on N-CoR involves preventing acetylation and subsequent degradation, thereby modulating its activity. Pargyline, a monoamine oxidase (MAO) inhibitor, indirectly influences N-CoR through altered levels of monoamines, impacting downstream signaling pathways and transcriptional regulation. JQ1 and PFI-1, BET bromodomain inhibitors, modulate N-CoR by disrupting interactions with bromodomain-containing proteins, affecting gene expression. Guanabenz, an alpha-2 adrenergic receptor agonist, influences N-CoR through downstream signaling pathways, impacting its transcriptional regulatory role. Lastly, Progesterone, a steroid hormone, influences N-CoR through progesterone receptor signaling, altering the dynamics of the corepressor complex and contributing to transcriptional modulation.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Apicidin

183506-66-3sc-202061
sc-202061A
1 mg
5 mg
$108.00
$336.00
9
(1)

Apicidin, characterized by its intricate molecular architecture, demonstrates unique reactivity patterns as an n-cor. It engages in selective acylation reactions, facilitated by its ability to stabilize reactive intermediates. The compound's distinctive electronic properties allow for effective π-stacking interactions, influencing its solubility and aggregation behavior. Additionally, Apicidin's interactions with nucleophiles are governed by its steric and electronic environment, leading to varied reaction kinetics in diverse conditions.

Bexarotene

153559-49-0sc-217753
sc-217753A
10 mg
100 mg
$54.00
$245.00
6
(1)

Retinoid X receptor (RXR) agonist, impacting N-CoR by facilitating the dissociation of corepressor complexes, thus indirectly modulating N-CoR.

AM 580

102121-60-8sc-203505
sc-203505A
5 mg
25 mg
$97.00
$382.00
2
(1)

Retinoic acid receptor (RAR) agonist, indirectly influencing N-CoR by modulating retinoic acid receptor signaling pathways.

Niclosamide

50-65-7sc-250564
sc-250564A
sc-250564B
sc-250564C
sc-250564D
sc-250564E
100 mg
1 g
10 g
100 g
1 kg
5 kg
$37.00
$77.00
$184.00
$510.00
$1224.00
$5814.00
8
(1)

STAT3 inhibitor influencing N-CoR through the JAK/STAT pathway, preventing N-CoR phosphorylation and promoting its transcriptional activity.

C646

328968-36-1sc-364452
sc-364452A
10 mg
50 mg
$260.00
$925.00
5
(1)

p300/CBP histone acetyltransferase (HAT) inhibitor, impacting N-CoR by preventing acetylation and subsequent degradation, modulating its activity.

Pargyline hydrochloride

306-07-0sc-215676
sc-215676A
500 mg
1 g
$39.00
$82.00
2
(1)

Monoamine oxidase (MAO) inhibitor, indirectly affecting N-CoR through altered levels of monoamines, influencing downstream signaling pathways.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$226.00
$846.00
1
(0)

BET bromodomain inhibitor, modulating N-CoR indirectly by interfering with bromodomain-containing proteins, affecting transcriptional regulation.

Guanabenz acetate

23256-50-0sc-203590
sc-203590A
sc-203590B
sc-203590C
sc-203590D
100 mg
500 mg
1 g
10 g
25 g
$100.00
$459.00
$816.00
$4080.00
$7140.00
2
(2)

Alpha-2 adrenergic receptor agonist, influencing N-CoR through downstream signaling pathways, impacting its transcriptional regulatory role.

PFI-1

1403764-72-6sc-478504
5 mg
$96.00
(0)

BET bromodomain inhibitor, similarly affecting N-CoR by disrupting interactions with bromodomain-containing proteins, altering gene expression.

Progesterone

57-83-0sc-296138A
sc-296138
sc-296138B
1 g
5 g
50 g
$20.00
$51.00
$292.00
3
(1)

Steroid hormone influencing N-CoR through progesterone receptor signaling, impacting corepressor complex dynamics and transcriptional modulation.