N-CoR Antibody (F-1): sc-515934

N-CoR Antibody (F-1) is a mouse monoclonal IgM antibody that detects N-CoR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). N-CoR (F-1) antibody is available as the non-conjugated form. N-CoR protein, also known as Nuclear Receptor Corepressor 1, plays a crucial role in gene expression regulation by acting as a transcriptional repressor. N-CoR protein is primarily located in the nucleus, where N-CoR interacts with various nuclear receptors, including retinoic acid receptors and thyroid hormone receptors, to inhibit transcription in the absence of ligands. This interaction maintains cellular homeostasis and regulates developmental processes, as N-CoR release upon ligand binding allows for target gene activation necessary for processes such as differentiation and metabolism. N-CoR protein consists of 2,440 amino acids and features multiple domains that facilitate interaction with nuclear receptors, underscoring N-CoR′s importance in gene regulation. Using anti-N-CoR antibody (F-1) in research can provide insights into transcriptional repression mechanisms and retinoids′ role in developmental biology.

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N-CoR Antibody (F-1) References:

1. The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.  |  Bailey, P., et al. 1999. Mol Endocrinol. 13: 1155-68. PMID: 10406466
2. Multiple N-CoR complexes contain distinct histone deacetylases.  |  Jones, PL., et al. 2001. J Biol Chem. 276: 8807-11. PMID: 11254656
3. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.  |  Zhang, J., et al. 2002. Mol Cell. 9: 611-23. PMID: 11931768
4. N-CoR controls differentiation of neural stem cells into astrocytes.  |  Hermanson, O., et al. 2002. Nature. 419: 934-9. PMID: 12410313
5. Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.  |  Yang, N., et al. 1991. Proc Natl Acad Sci U S A. 88: 3559-63. PMID: 1850832
6. A functional retinoic acid receptor encoded by the gene on human chromosome 12.  |  Ishikawa, T., et al. 1990. Mol Endocrinol. 4: 837-44. PMID: 2172793
7. USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.  |  Lan, X., et al. 2016. Cell Rep. 17: 2382-2393. PMID: 27880911
8. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.  |  Hörlein, AJ., et al. 1995. Nature. 377: 397-404. PMID: 7566114
9. Polarity-specific activities of retinoic acid receptors determined by a co-repressor.  |  Kurokawa, R., et al. 1995. Nature. 377: 451-4. PMID: 7566126
10. A transcriptional co-repressor that interacts with nuclear hormone receptors.  |  Chen, JD. and Evans, RM. 1995. Nature. 377: 454-7. PMID: 7566127
11. Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.  |  Bhat, MK., et al. 1994. Proc Natl Acad Sci U S A. 91: 7927-31. PMID: 8058736
12. The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB.  |  Aasland, R., et al. 1996. Trends Biochem Sci. 21: 87-8. PMID: 8882580

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-N-CoR Antibody (F-1) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-N-CoR Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

N-CoR Antibody (F-1) Specifications

Alternate Product Name: NCOR1

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 2429-2453

Epitope Target: N-CoR

Epitope Species: mouse

Product Reactivity/Detection: N-CoR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for N-CoR Antibody (F-1): X: TransCruz Reagent

The preferred N-CoR antibody is N-CoR Antibody (E-6): sc-518134.