Myosin Id Activators
Myosin Id Activators are a diverse set of chemical compounds that indirectly enhance the functional activity of Myosin Id through modulation of intracellular signaling pathways. Forskolin and 8-Bromo-cAMP, by increasing cAMP levels, and Dibutyryl-cAMP, a cAMP analog, activate protein kinase A (PKA), which in turn can phosphorylate Myosin Id, thereby enhancing its motor function in the cell. Myosin Id activators encompass a variety of chemical compounds that enhance the protein's motor function through distinct biochemical signaling pathways. The activation mechanism of Myosin Id by calmodulin is initiated through calcium signaling, wherein calmodulin activates the MLCK, leading to the phosphorylation of the myosin light chain, thus stimulating Myosin Id's motor function. Similarly, PIP2 interaction with Myosin Id facilitates its ATPase activity, critical for actin-based motility.
Myosin Id activators are a diverse set of chemical compounds that indirectly enhance the functional activity of Myosin Id by modulating various signaling pathways intrinsic to Myosin Id's regulation. Calmodulin serves as a pivotal activator by binding to Myosin Id in a calcium-dependent manner, enabling the subsequent phosphorylation by myosin light chain kinase (MLCK), which is essential for Myosin Id's motor activity. Conversely, PIP2 binds directly to Myosin Id, modulating its conformation and thus enhancing ATPase activity, which is critical for its role in actin-based motility. Forskolin, through cAMP elevation, and A23187, by increasing intracellular calcium levels, both lead to the activation of kinases like PKA and MLCK, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate Myosin Id, thus enhancing Myosin Id's motor activity in cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a variety of substrates including Myosin Id. PKC-mediated phosphorylation of Myosin Id may increase its activity in cytoskeletal reorganization. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), which prevents dephosphorylation of proteins. Inhibition of these phosphatases maintains Myosin Id in a phosphorylated and thus activated state. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Similar to Calyculin A, Okadaic Acid inhibits PP1 and PP2A, leading to increased phosphorylation levels of cellular proteins. This promotes the activation of Myosin Id by keeping it in a phosphorylated state. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to phosphorylation and subsequent activation of Myosin Id, thereby enhancing its role in cellular processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium/calmodulin-dependent kinase (CaMK), which may phosphorylate and activate Myosin Id. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits a range of kinases, which can alter signaling pathways and reduce competitive phosphorylation events, potentially leading to an increased activation of Myosin Id through non-inhibited kinases. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC. Inhibition of certain PKC isoforms can lead to compensatory activation of other pathways that may include PKA, indirectly leading to the activation of Myosin Id. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is another cell-permeable analog of cAMP which activates PKA. PKA then can phosphorylate Myosin Id, promoting its activity in motility and contractility within the cell. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore, like Ionomycin, which elevates intracellular calcium levels, possibly leading to the activation of Myosin Id by calcium-dependent kinases. | ||||||