Myosin Id Inhibitors
Myosin Id inhibitors represent a distinct class of chemical compounds that specifically target the myosin Id isoform. Myosins are motor proteins involved in various cellular processes, primarily the generation of mechanical force and movement along actin filaments. The myosin Id isoform is a subtype within the myosin family, and its inhibition is a subject of interest in the realm of cell biology and molecular pharmacology. Structurally, myosin Id possesses characteristic features that distinguish it from other myosin isoforms, and inhibitors tailored to interact selectively with this subtype have been developed.
These inhibitors typically exert their effects by interfering with the enzymatic activity of myosin Id. This enzymatic activity involves the hydrolysis of ATP to ADP and inorganic phosphate, facilitating the conversion of chemical energy into mechanical work. Myosin Id inhibitors disrupt this process, modulating the protein's function and consequently influencing cellular activities reliant on myosin-mediated processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Selectively binds to myosin II and inhibits its ATPase activity, leading to the inhibition of myosin II motility. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibits myosin light chain kinase, which can decrease phosphorylation of myosin light chains, thus inhibiting contraction. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits ROCK, which is involved in phosphorylating myosin light chains, thus can reduce myosin-mediated contraction. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
Calmodulin antagonist, which can interfere with myosin light chain kinase activity and thus myosin function. | ||||||
2,3-Butanedione 2-Monoxime | 57-71-6 | sc-203774 sc-203774A sc-203774B sc-203774C | 25 g 100 g 250 g 500 g | $42.00 $78.00 $161.00 $286.00 | ||
Reduces myosin ATPase activity, which can lead to reduced myosin function. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
Inhibits ROCK, affecting myosin light chain phosphorylation and myosin-mediated functions. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Inhibits formin-mediated actin polymerization, which can indirectly affect myosin activity. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits the ATPase activity of myosin II, similar to its non-stereoisomer counterpart. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds to actin and prevents its polymerization, indirectly affecting myosin's ability to interact with actin. | ||||||