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Latrunculin A, Latrunculia magnifica (CAS 76343-93-6)

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Alternate Names:
Latrunculin A, Latrunculia magnifica is also known as LAT-A.
Application:
Latrunculin A, Latrunculia magnifica is a stabilizer of monomeric G-actin and polymerization inhibitor that disrupts microfilament organization in cultured cells.
CAS Number:
76343-93-6
Purity:
≥96%
Molecular Weight:
421.55
Molecular Formula:
C22H31NO5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Latrunculin A, Latrunculia magnifica is a natural compound found in the marine sponge Latrunculia magnifica, known for its potent activity in disrupting microfilament organization in eukaryotic cells. In research applications, Latrunculin A, Latrunculia magnifica is widely used to study the dynamics of the actin cytoskeleton. By binding to monomeric actin (G-actin), Latrunculin A, Latrunculia magnifica prevents the polymerization into filamentous actin (F-actin), thus leading to a depolymerization of actin filaments. This specific mechanism is for understanding cell motility, division, and morphology. Research involving Latrunculin A, Latrunculia magnifica has shed light on various cellular processes that depend on the actin cytoskeleton, including the investigation of cell signaling pathways, intracellular trafficking, and the impact of actin disruption on cell function and structure. The compound is also instrumental in exploring the potential effects of cytoskeletal inhibitors on cellular processes, which can have implications in understanding certain conditions where actin polymerization is a key factor.


Latrunculin A, Latrunculia magnifica (CAS 76343-93-6) References

  1. Autoregulation of actin synthesis requires the 3'-UTR of actin mRNA and protects cells from actin overproduction.  |  Lyubimova, A., et al. 1999. J Cell Biochem. 76: 1-12. PMID: 10580995
  2. Actin-latrunculin A structure and function. Differential modulation of actin-binding protein function by latrunculin A.  |  Yarmola, EG., et al. 2000. J Biol Chem. 275: 28120-7. PMID: 10859320
  3. Characterization of the activities of actin-affecting drugs on tumor cell migration.  |  Hayot, C., et al. 2006. Toxicol Appl Pharmacol. 211: 30-40. PMID: 16005926
  4. Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum.  |  Smythe, WA., et al. 2008. Cell Microbiol. 10: 452-64. PMID: 17944961
  5. Different microtubule motors move early and late endocytic compartments.  |  Loubéry, S., et al. 2008. Traffic. 9: 492-509. PMID: 18194411
  6. Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants.  |  Radjasa, OK., et al. 2011. Bioorg Med Chem. 19: 6658-74. PMID: 21835627
  7. The actin depolymerizing factor (ADF)/cofilin signaling pathway and DNA damage responses in cancer.  |  Chang, CY., et al. 2015. Int J Mol Sci. 16: 4095-120. PMID: 25689427
  8. Disruption of the association between drug transporter and actin cytoskeleton abolishes drug resistance in hypertrophic scar.  |  Su, L., et al. 2017. Oncotarget. 8: 2617-2627. PMID: 27926506
  9. An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.  |  Hu, JK., et al. 2017. Cell Stem Cell. 21: 91-106.e6. PMID: 28457749
  10. Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process.  |  Davies, SP., et al. 2019. Cell Rep. 29: 1610-1620.e4. PMID: 31693899
  11. Histone methyltransferase activity programs nuclear peripheral genome positioning.  |  See, K., et al. 2020. Dev Biol. 466: 90-98. PMID: 32712024
  12. The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells.  |  Wang, B., et al. 2020. Proc Natl Acad Sci U S A. 117: 28307-28315. PMID: 33122440
  13. Serotonin 2A (5-HT2A) receptor affects cell-matrix adhesion and the formation and maintenance of stress fibers in HEK293 cells.  |  John Jayakumar, JAK., et al. 2020. Sci Rep. 10: 21675. PMID: 33303826
  14. PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding.  |  Soares, AC., et al. 2021. J Biol Chem. 296: 100636. PMID: 33831417
  15. Actin-dependent membrane polarization reveals the mechanical nature of the neuroblast polarity cycle.  |  LaFoya, B. and Prehoda, KE. 2021. Cell Rep. 35: 109146. PMID: 34010656
  16. Inhibition of actin polymerization by latrunculin A.  |  Coué, M., et al. 1987. FEBS Lett. 213: 316-8. PMID: 3556584

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Latrunculin A, Latrunculia magnifica, 100 µg

sc-202691
100 µg
$260.00

Latrunculin A, Latrunculia magnifica, 500 µg

sc-202691B
500 µg
$799.00

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. Latrunculin A, Latrunculia magnifica (CAS 76343-93-6) is soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml).
Answered by: Technical Support
Date published: 2020-09-23
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Rated 5 out of 5 by from The chain reactionWe fully bind to the adrenal chemical enzyme and stabilize G-globular actin, catalyze the conversion of G-globular actin into filamentous F-actin, disrupting the cells in the cell tissue, detailing the catalytic chemical chain reaction
Date published: 2017-02-12
Rated 5 out of 5 by from LiuLiu, et. al. (PubMed ID 12873448) found that recovery of human trabecular meshwork (HTM) cells was quickened by treating them with latrunculin A post dexamethasone treatment/removal. -SCBT Publication Review
Date published: 2015-03-20
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Latrunculin A, Latrunculia magnifica is rated 5.0 out of 5 by 2.
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