Molecular structure of SMIFH2, CAS Number: 340316-62-3
SMIFH2 (CAS 340316-62-3)
Alternate Names:
1-(3-bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
CAS Number:
340316-62-3
Purity:
≥98% (mixture of isomers)
Molecular Weight:
377.2
Molecular Formula:
C15H9BrN2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SMIFH2 is a chemical compound widely recognized for its role as an inhibitor of the formin family of proteins, which play a crucial role in the regulation of actin polymerization. Specifically, SMIFH2 has garnered attention for its ability to disrupt the interaction between formin proteins and actin, thereby inhibiting the assembly of actin filaments. Actin, a globular protein that forms long polymer chains, is essential for various cellular processes, including cell motility, division, and maintenance of cell shape. By targeting the formin-mediated actin assembly pathway, SMIFH2 directly influences the dynamics of actin filament formation. This inhibition is particularly significant because beta-actin, a predominant form of actin in cells, is crucial for the formation of cellular structures such as lamellipodia and filopodia, which are vital for cell movement and adhesion.
SMIFH2 (CAS 340316-62-3) References
- SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton. | Isogai, T., et al. 2015. Sci Rep. 5: 9802. PMID: 25925024
- SMIFH2-mediated mDia formin functional inhibition potentiates chemotherapeutic targeting of human ovarian cancer spheroids. | Ziske, MA., et al. 2016. Biochem Biophys Res Commun. 472: 33-9. PMID: 26898799
- SMIFH2 inhibition of platelets demonstrates a critical role for formin proteins in platelet cytoskeletal dynamics. | Green, HLH., et al. 2020. J Thromb Haemost. 18: 955-967. PMID: 31930764
- The formin inhibitor SMIFH2 inhibits members of the myosin superfamily. | Nishimura, Y., et al. 2021. J Cell Sci. 134: PMID: 33589498
- Analysis of formin functions during cytokinesis using specific inhibitor SMIFH2. | Zhang, L., et al. 2021. Plant Physiol. 186: 945-963. PMID: 33620500
- Differential effects of the formin inhibitor SMIFH2 on contractility and Ca2+ handling in frog and mouse cardiomyocytes. | Sakata, K., et al. 2021. Genes Cells. 26: 583-595. PMID: 34060165
- Alterations to the broad-spectrum formin inhibitor SMIFH2 modulate potency but not specificity. | Orman, M., et al. 2022. Sci Rep. 12: 13520. PMID: 35941181
- Abnormal left-right organizer and laterality defects in Xenopus embryos after formin inhibitor SMIFH2 treatment. | Petri, N., et al. 2022. PLoS One. 17: e0275164. PMID: 36342927
- Investigating Mammalian Formins with SMIFH2 Fifteen Years in: Novel Targets and Unexpected Biology. | Innocenti, M. 2023. Int J Mol Sci. 24: PMID: 37240404
- The formins inhibitor SMIFH2 inhibits the cytoskeleton dynamics and mitochondrial function during goat oocyte maturation. | Pan, MH., et al. 2023. Theriogenology. 211: 40-48. PMID: 37562190
Inhibitor of:
α-actinin-3, α-actinin-4, β1-Syntrophin, 3110003A17Rik, 4921517D21Rik, 4930488E11Rik, 6230427J02Rik, 6720456B07Rik, ABLIM1, ABLIM2, ACTBL1, ACTC1, ACTG2, Actin related protein 2/3 (ARP2/3), ACTL10, ACTL7A, ACTL7B, ACTR10, Adducin β, AFAP-110, AGAP1, ANK-1, ArgBP2, ARHGEF10, ARHGEF19, Astrotactin, BAIAP2L2, BC055111, beta-Actin, CAP1, CCDC38, CCDC53, CLP36, COBLL1, Cofilin 1, Cofilin 2, Cordon-bleu, Coronin 1C, Coronin 2A, Coronin 6, DENND1A, DENND5B, DIAPH3, EHBP1L1, EPI64, Espin, FAM160A2, FAM21A, FAM21C, FAM39E, FBF1, FBLIM1, FBP21, FGD6, FHOD1, FHOD3, Filamin 1, Filamin 2, Filamin 3, Flightless I, FNBP1L, Formin 2, Formin Like (FMNL1, FMNL2), Gas2L2, Gm732, Gm949, GMF-γ, GMIP, GOLGA8J, GOLGA8R, HMP-2, HSPC300, INF2, IPP, IRSp53, KIAA0754, KLHDC9, L-Plastin, Lad, Lamellipodin, Las17, Leiomodin 3, LIN-10, LRCH3, LRRC16B, LSP1, LURAP1, LUZP1, Mena, MICAL1, Moesin, MORN1, MRTF-A, MRTF-B, Muscle Actin, MYBPH, MYH2, MYH8, Myocardin, myopalladin, Myosin Ic, Myosin Id, Myosin Ig, Myosin IIIa, Myosin Vc, Myosin VIIB, Myosin X, Myosin-13, Myosin-XVA, Myotilin, N-RAP, NCKAP5L, Nebulin, NET1, netrin-4, NHS, NHSL1, Obscurin, Odf3, ORF19, PACS-1b, PACSIN3, periaxin, PHACTR2, PHACTR4, PIPK III, plakophilin 4, PLEKHG2, PLEKHH3, POR1, Profilin, Profilin-1, Profilin-4, Rab 16, Rab 23, Rab 3D, Rab 9B, Rab11-FIP1, Rab11-FIP2, Rab11-FIP4, Rabaptin-5β, Rac 2, Reticulon, RGNEF, Rho GAP p190, RICS, RIM-BP2, RIN3, RINL, RNF103-CHMP3, Sec15B, SEMA6B, Septin 10, Septin 3, SERINC5, shootin1, SHROOM1, SIPA1L, Smooth Muscle Actin, SNAPC 50, SPACA1, Spir-1, Spir-2, STARD, StARD13, Strumpellin, Synaptopodin, Syne-3, Syne-4, syntenin-2, T-Plastin, Tβ-15a, TANC, TMED8, transgelin-3, Tropomyosin, Tropomyosin 4, Troponin I-FS, UNC45B, Veli1, VPS13A, Wip1, WIRE, Xinα, Xinβ, zygin 1, and Zyxin.Activator of:
ARHGAP24, ARHGAP30, Arp3, Arp3β, ARPC5L, BC055107, BC057079, Cdc42EP2, Cofilin 1, Coronin 1B, Dynactin 1, EVL, FCHO1, Formin 1, GRF-1, HRF, INF2, LIMK-1, MSE55, MYH9, Myosin Va, Myosin VI, Myosin XVIIIb, PDZ-RhoGEF, RAb 19B, SNX18, SRGAP1, tropomodulin 1, tropomodulin 3, Twinfilin-1, Vac17p, and vinculin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMIFH2, 5 mg | sc-507273 | 5 mg | $140.00 |