MYLK3 Inhibitors
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which is involved in the phosphorylation of myosin light chains. By inhibiting MLCK, it indirectly prevents MYLK3 from phosphorylating myosin light chains, leading to the inhibition of MYLK3's role in muscle contraction and cellular motility. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
ML-9, like ML-7, inhibits MLCK and thereby reduces the phosphorylation activity on myosin light chains. Since MYLK3 is a kinase that can phosphorylate myosin light chains, inhibition of MLCK by ML-9 will reduce the substrate availability for MYLK3, leading to its functional inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it disrupts the PI3K/AKT pathway that is crucial for many cellular processes including actin cytoskeleton reorganization, where MYLK3 is involved. Inhibition of this pathway leads to the functional inhibition of MYLK3. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum inhibitor of protein kinases. It inhibits protein kinase C (PKC) which is involved in the same signaling pathways as MYLK3, particularly in the regulation of muscle contraction. Inhibition of PKC can decrease the phosphorylation of downstream targets, indirectly inhibiting MYLK3. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is an inhibitor of protein kinase A (PKA). By inhibiting PKA, it can reduce the phosphorylation of targets within the same pathway as MYLK3, leading to an indirect inhibition of MYLK3's kinase activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of ROCK (Rho-associated protein kinase), which is involved in regulating actin cytoskeleton dynamics and contraction. As MYLK3 is also implicated in cytoskeletal dynamics through phosphorylation of myosin light chains, inhibition of ROCK can lead to a decrease in MYLK3's functional activity. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Gö 6976 is an inhibitor of calcium/calmodulin-dependent protein kinases. Since MYLK3 is a kinase that can be regulated by calcium signaling, inhibition of these kinases can reduce the phosphorylation of target proteins, leading to the functional inhibition of MYLK3. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Inhibition of CaMKII can affect the calcium signaling pathways that are necessary for MYLK3 function, resulting in an indirect inhibition of MYLK3's activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which is upstream of the ERK pathway. By inhibiting MEK, the activation of downstream kinases is prevented. As MYLK3 is involved in pathways regulated by ERK, its functional activity is inhibited by the reduction in ERK signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is a specific inhibitor of p38 MAP kinase. Inhibition of p38 MAPK can disrupt stress response and inflammatory signaling pathways where MYLK3 might be involved. This inhibition can decrease MYLK3's kinase activity. | ||||||