MYH6 Activators
MYH6, also known as cardiac myosin heavy chain alpha, is a crucial component of the sarcomere, the basic contractile unit of cardiac muscle. As a motor protein, MYH6 plays a central role in the generation of force during cardiac contraction. Specifically, MYH6 is responsible for converting chemical energy into mechanical work by interacting with actin filaments, resulting in the sliding of these filaments and subsequent muscle contraction. In the context of cardiac muscle, MYH6 contributes to the efficient pumping of blood throughout the body, thus supporting overall cardiovascular function and maintaining systemic perfusion.
Activation of MYH6 involves a complex cascade of signaling events that regulate its activity within the sarcomere. One key mechanism of activation involves the phosphorylation of specific residues on MYH6 by protein kinases, such as protein kinase A (PKA) and protein kinase C (PKC). Phosphorylation of MYH6 alters its conformation and enhances its interaction with other sarcomeric proteins, promoting the formation of cross-bridges between actin and myosin filaments and facilitating muscle contraction. Additionally, intracellular calcium signaling plays a crucial role in the activation of MYH6. Calcium ions bind to regulatory proteins, including troponin and tropomyosin, leading to conformational changes that expose binding sites on actin filaments for myosin heads, thereby promoting cross-bridge formation and muscle contraction. Moreover, various signaling pathways, such as those involving beta-adrenergic receptors and G-protein coupled receptors, modulate MYH6 activity in response to physiological and pathological stimuli, further contributing to its activation and regulation in cardiac muscle.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK). Activation of AMPK can modulate cellular energy status and downstream signaling pathways, potentially influencing MYH6 expression. AMPK activation may lead to altered transcriptional regulation, including the regulation of MYH6 gene expression. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516 is a peroxisome proliferator-activated receptor-delta (PPARδ) agonist. PPARδ activation can impact cardiac gene expression, and it has been implicated in the regulation of myocardial hypertrophy and contractility. Modulation of PPARδ signaling may indirectly influence MYH6 expression through alterations in the transcriptional regulatory network governing cardiac gene expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased intracellular levels of cyclic adenosine monophosphate (cAMP). Elevated cAMP levels can activate protein kinase A (PKA), which may influence downstream signaling cascades, including pathways involved in cardiac gene expression. The modulation of PKA signaling has the potential to affect MYH6 expression, contributing to the regulation of cardiac contractile proteins. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable analog of cAMP. It directly elevates intracellular cAMP levels, activating downstream signaling pathways. Similar to Forskolin, the increased cAMP levels can activate PKA and potentially influence pathways governing cardiac gene expression, including MYH6. Modulation of cAMP/PKA signaling may contribute to the regulation of MYH6 expression and cardiac contractility. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic receptor agonist that activates the beta-adrenergic signaling pathway. Stimulation of beta-adrenergic receptors leads to increased cAMP production and PKA activation. The subsequent signaling cascades may impact cardiac gene expression, potentially influencing MYH6 transcription. Beta-adrenergic receptor activation is a key regulator of cardiac function, and its modulation can affect MYH6 expression and cardiac contractility. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 mitogen-activated protein kinase (MAPK). Inhibition of p38 MAPK can influence various cellular processes, including gene expression. MYH6 expression may be indirectly affected by SB203580 through its impact on p38 MAPK signaling, which plays a role in the regulation of cardiac hypertrophy and gene transcription. The modulation of this pathway has the potential to alter MYH6 expression and contribute to changes in cardiac contractile properties. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor that can modulate chromatin structure and gene expression. It may impact MYH6 expression through its ability to alter histone acetylation patterns, influencing the accessibility of the MYH6 gene for transcription. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, also known as adrenaline, is a hormone and neurotransmitter that activates adrenergic receptors. Similar to Isoproterenol, the activation of adrenergic receptors by Epinephrine can stimulate the beta-adrenergic signaling pathway, leading to increased cAMP levels and PKA activation. This signaling cascade may influence MYH6 expression and contribute to the regulation of cardiac contractility. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $127.00 | 18 | |
Losartan is an angiotensin II receptor antagonist used to treat hypertension. By blocking the angiotensin II receptor, Losartan can influence the activity of the RAAS. The modulation of RAAS activity may indirectly impact MYH6 expression, contributing to changes in cardiac gene regulation and contractile function. Losartan's effects on the RAAS pathway provide a potential avenue for the modulation of MYH6 expression in the context of cardiac physiology and pathology. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine is a neurotransmitter and hormone that activates adrenergic receptors. Its stimulation of adrenergic receptors can initiate signaling cascades similar to Epinephrine and Isoproterenol, leading to increased cAMP production and PKA activation. The downstream effects of this pathway may influence MYH6 expression, contributing to the regulation of cardiac contractility. | ||||||