MUP21 Inhibitors
MUP21 inhibitors are a class of compounds that target Major Urinary Protein 21 (MUP21), a protein involved in the binding and transport of pheromones, particularly in rodent species. MUP21, as part of the broader MUP family, plays a crucial role in the communication systems of animals by binding small, hydrophobic molecules like pheromones, which are secreted in urine. These proteins allow for the slow release of these pheromones into the environment, facilitating signaling mechanisms that influence social behaviors such as territory marking, reproductive behavior, and individual recognition. MUP21 inhibitors function by blocking the interaction between MUP21 and its pheromone ligands, thus disrupting the natural processes that regulate pheromone dissemination and perception.
In research contexts, MUP21 inhibitors are useful tools for investigating the molecular and structural dynamics of pheromone-binding proteins. By inhibiting MUP21's ability to bind pheromones, researchers can explore the specific role of this protein in social and behavioral processes within animal populations, particularly rodents. This allows scientists to study how the inhibition of MUP21 affects pheromone-related behaviors, providing insights into the complex chemical signaling pathways that underlie social interactions. Additionally, MUP21 inhibitors contribute to the understanding of the structural biology of MUP proteins, helping to define the critical regions and residues involved in ligand binding. Through such studies, these inhibitors can elucidate the broader biological significance of MUPs and their interaction with chemical signals in the environment.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Inhibits GPCR signaling crucial for Mup21's predicted odorant binding activity. Pertussis Toxin disrupts GPCR signaling, indirectly inhibiting Mup21 in the extracellular space where the protein is active. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Targets Matrix Metalloproteinases (MMPs), influencing Extracellular Matrix (ECM) remodeling. Indirectly inhibits Mup21's odorant binding by modulating ECM, impacting the extracellular space where Mup21 is predicted to be active. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Inhibits SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase), disrupting intracellular calcium homeostasis. Indirectly inhibits Mup21's odorant binding by affecting calcium-dependent signaling pathways in the extracellular space. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Induces calcium influx by facilitating ion transport across the cell membrane. Ionomycin disrupts intracellular calcium homeostasis, indirectly inhibiting Mup21's odorant binding by influencing calcium-dependent signaling pathways in the extracellular space. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K/AKT pathway associated with Mup21. LY294002 indirectly inhibits odorant binding by disrupting PI3K/AKT signaling, impacting the extracellular space where Mup21 is predicted to exert its function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Blocks SERCA, disrupting intracellular calcium homeostasis. Thapsigargin indirectly inhibits Mup21's odorant binding by affecting calcium-dependent signaling pathways in the extracellular space. | ||||||
TAPI-1 | 171235-71-5 | sc-222337 | 1 mg | $669.00 | 15 | |
Inhibits ADAM (A Disintegrin And Metalloproteinase) family enzymes. TAPI-1 influences Extracellular Matrix (ECM) remodeling, indirectly inhibiting Mup21's odorant binding by modulating the ECM in the extracellular space. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Targets the MEK/ERK pathway influencing odorant binding activity. U0126 disrupts MEK/ERK signaling, indirectly inhibiting Mup21's predicted function in the extracellular space. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Irreversible PI3K inhibitor affecting Mup21. Wortmannin disrupts PI3K/AKT signaling, indirectly inhibiting Mup21's odorant binding activity in the extracellular space. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Specifically inhibits Rac1, a GTPase involved in cytoskeletal reorganization. NSC 23766 indirectly inhibits Mup21's odorant binding by affecting GTPase signaling in the extracellular space. | ||||||