MUM1 Activators
MUM1, also known as Melanoma-associated antigen (mutated) 1 or Multiple Myeloma Oncogene 1, encoded by the IRF4 gene, is a member of the interferon regulatory factor (IRF) family of transcription factors. It is widely recognized for its role in the immune system and oncogenesis. MUM1/IRF4 is particularly important in the differentiation and function of B cells and T cells, influencing the production of immunoglobulins in plasma cells and impacting the immune response.Overexpression of MUM1 has been observed in various hematologic malignancies, including multiple myeloma and certain types of non-Hodgkin lymphoma, where it serves as a prognostic indicator and a potential target. Its expression is also used as a marker in the diagnostic evaluation of lymphoid neoplasms.
The protein functions by binding to specific DNA sequences and regulating the transcription of genes involved in cell growth, apoptosis, and the immune response. Given its role in cell cycle regulation and apoptosis, MUM1/IRF4's dysregulation is implicated in the pathogenesis of several cancers.Research into MUM1 not only enhances the understanding of tumor biology but also guides the development of immuno strategies. It is considered a promising candidate for targeted therapy due to its restricted expression pattern in the immune system and its involvement in tumorigenesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor could potentially activate MUM1 expression by demethylation of its promoter region. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As an HDAC inhibitor, it might enhance the transcription of MUM1 by altering chromatin accessibility. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another HDAC inhibitor that could hypothetically increase MUM1 expression through epigenetic modifications. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
This short-chain fatty acid may act as an HDAC inhibitor, possibly affecting MUM1 gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
This compound could regulate MUM1 expression through retinoid signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
TPA activates protein kinase C which could induce MUM1 expression as part of a signaling cascade. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
As a selective estrogen receptor modulator, tamoxifen might influence MUM1 expression by modulating hormone signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
This mTOR inhibitor could affect MUM1 expression by modulating cellular growth and proliferation signals. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A hypomethylating agent that could induce MUM1 expression by DNA demethylation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a synthetic glucocorticoid, it could potentially enhance MUM1 expression through glucocorticoid receptor-mediated pathways. | ||||||