MUM1 Antibody (D-11): sc-514332

MUM1 Antibody (D-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects MUM1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MUM1 Antibody (D-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MUM1 protein, also known as melanoma associated antigen (mutated) 1, is a 710 amino acid protein that plays a crucial role in cellular response to DNA damage, as MUM1 becomes phosphorylated by Ataxia Telangiectasia Mutated (ATM) or ATM and Rad3-related (ATR) kinases. This phosphorylation is essential for activation of DNA repair pathways, highlighting MUM1′s importance in maintaining genomic stability and preventing tumorigenesis. The gene encoding MUM1 is located on human chromosome 19, a region known for high gene density and housing numerous immunoglobulin superfamily members, which are vital for immune response and cell signaling. Anti-MUM1 antibody (D-11) is an invaluable tool for researchers studying mechanisms of DNA damage response and implications in cancer biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MUM1 Antibody (D-11) References:

1. C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers.  |  Wang, L., et al. 2000. Clin Cancer Res. 6: 2988-93. PMID: 10955775
2. Comparative human-mouse-rat sequence analysis of the ICAM gene cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q.  |  Leeb, T. and Müller, M. 2004. Gene. 343: 239-44. PMID: 15588578
3. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.  |  Matsuoka, S., et al. 2007. Science. 316: 1160-6. PMID: 17525332
4. The extended human leukocyte receptor complex: diverse ways of modulating immune responses.  |  Barrow, AD. and Trowsdale, J. 2008. Immunol Rev. 224: 98-123. PMID: 18759923
5. Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700-kb cosmid contig spanning the region.  |  Olsen, A., et al. 1994. Genomics. 23: 659-68. PMID: 7851895
6. The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family.  |  Teglund, S., et al. 1994. Genomics. 23: 669-84. PMID: 7851896

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MUM1 Antibody (D-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MUM1 Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MUM1 Antibody (D-11) Specifications

Alternate Product Name: MUM1

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 72-96

Epitope Target: MUM1

Epitope Species: human

Product Reactivity/Detection: MUM1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MUM1 Antibody (D-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin